A NSQIP-based randomized clinical trial evaluating choice of prophylactic antibiotics for pancreaticoduodenectomy Review
| Authors: | Brajcich, B. C.; Ko, C. Y.; Liu, J. B.; Ellis, R. J.; D’Angelica, M. I. |
| Review Title: | A NSQIP-based randomized clinical trial evaluating choice of prophylactic antibiotics for pancreaticoduodenectomy |
| Abstract: | Surgical site infection after pancreaticoduodenectomy is often caused by pathogens resistant to standard prophylactic antibiotics, suggesting that broad-spectrum antibiotics may be more effective prophylactic agents. This article describes the rationale and methodology underlying a multicenter randomized trial evaluating piperacillin–tazobactam compared with cefoxitin for surgical site infection prevention following pancreaticoduodenectomy. As the first US randomized surgical trial to utilize a clinical registry for data collection, this study serves as proof of concept for registry-based clinical trials. © 2021 Wiley Periodicals LLC |
| Keywords: | clinical trial; pancreaticoduodenectomy; antibiotic prophylaxis; surgical wound infection; piperacillin; cefoxitin; tazobactam drug combination |
| Journal Title: | Journal of Surgical Oncology |
| Volume: | 123 |
| Issue: | 6 |
| ISSN: | 0022-4790 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2021-05-01 |
| Start Page: | 1387 |
| End Page: | 1394 |
| Language: | English |
| DOI: | 10.1002/jso.26402 |
| PUBMED: | 33831250 |
| PROVIDER: | scopus |
| PMCID: | PMC8041048 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 3 May 2021 -- Source: Scopus |
