Mammographic texture features associated with contralateral breast cancer in the WECARE Study Journal Article


Authors: Watt, G. P.; Knight, J. A.; Lin, C.; Lynch, C. F.; Malone, K. E.; John, E. M.; Bernstein, L.; Brooks, J. D.; Reiner, A. S.; Liang, X.; Woods, M.; Nguyen, T. L.; Hopper, J. L.; Pike, M. C.; Bernstein, J. L.
Article Title: Mammographic texture features associated with contralateral breast cancer in the WECARE Study
Abstract: To evaluate whether mammographic texture features were associated with second primary contralateral breast cancer (CBC) risk, we created a “texture risk score” using pre-treatment mammograms in a case–control study of 212 women with CBC and 223 controls with unilateral breast cancer. The texture risk score was associated with CBC (odds per adjusted standard deviation = 1.25, 95% CI 1.01–1.56) after adjustment for mammographic percent density and confounders. These results support the potential of texture features for CBC risk assessment of breast cancer survivors. © 2021, The Author(s).
Keywords: cancer survival; controlled study; major clinical study; case control study; radiation dose; breast cancer; risk factor; cancer survivor; risk assessment; body mass; mammography; cancer epidemiology; estrogen receptor; progesterone receptor; menopause; postmenopause; structured questionnaire; tumor invasion; human; female; article
Journal Title: npj Breast Cancer
Volume: 7
ISSN: 2374-4677
Publisher: Nature Publishing Group  
Date Published: 2021-11-29
Start Page: 146
Language: English
DOI: 10.1038/s41523-021-00354-1
PROVIDER: scopus
PMCID: PMC8630158
PUBMED: 34845211
DOI/URL:
Notes: Article -- Export Date: 3 January 2022 -- Source: Scopus
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  1. Anne S Reiner
    248 Reiner
  2. Malcolm Pike
    190 Pike
  3. Jonine L Bernstein
    142 Bernstein
  4. Xiaolin Liang
    62 Liang
  5. Meghan   Woods
    30 Woods
  6. Gordon Patrick Watt
    16 Watt