Alcohol consumption and cigarette smoking in combination: A predictor of contralateral breast cancer risk in the WECARE study Journal Article


Authors: Knight, J. A.; Fan, J.; Malone, K. E.; John, E. M.; Lynch, C. F.; Langballe, R.; Bernstein, L.; Shore, R. E.; Brooks, J. D.; Reiner, A. S.; Woods, M.; Liang, X.; Bernstein, J. L.; on behalf of the Wecare Study Collaborative Group
Contributors: Capanu, M.; Orlow, I.; Robson, M.
Article Title: Alcohol consumption and cigarette smoking in combination: A predictor of contralateral breast cancer risk in the WECARE study
Abstract: Alcohol drinking and, to a lesser extent, cigarette smoking are risk factors for a first primary breast cancer. Information on these behaviours at diagnosis may contribute to risk prediction of contralateral breast cancer (CBC) and they are potentially modifiable. The WECARE Study is a large population-based case-control study of women with breast cancer where cases (N = 1,521) had asynchronous CBC and controls (N = 2,212), matched on survival time and other factors, had unilateral breast cancer (UBC). Using multivariable conditional logistic regression to estimate rate ratios (RR) and 95% confidence intervals (CI), we examined the risk of CBC in relation to drinking and smoking history at and following first diagnosis. We adjusted for treatment, disease characteristics and other factors. There was some evidence for an association between CBC risk and current drinking or current smoking at the time of first breast cancer diagnosis, but the increased risk occurred primarily among women exposed to both (RR = 1.62, 95% CI 1.24–2.11). CBC risk was also elevated in women who both smoked and drank alcohol after diagnosis (RR = 1.54, 95% CI 1.18–1.99). In the subset of women with detailed information on amount consumed, smoking an average of ≥10 cigarettes per day following diagnosis was also associated with increased CBC risk (RR = 1.50, 95% CI 1.08–2.08; p-trend = 0.03). Among women with a diagnosis of breast cancer, information on current drinking and smoking could contribute to the prediction of CBC risk. Women who both drink and smoke may represent a group who merit targeted lifestyle intervention to modify their risk of CBC. © 2017 UICC
Keywords: adult; controlled study; aged; major clinical study; cancer risk; demography; disease association; breast cancer; smoking; survival time; alcohol; alcohol consumption; disease predisposition; population based case control study; health assessment questionnaire; contralateral breast cancer; case-control study; unilateral breast cancer; human; female; priority journal; article
Journal Title: International Journal of Cancer
Volume: 141
Issue: 5
ISSN: 0020-7136
Publisher: John Wiley & Sons  
Date Published: 2017-09-01
Start Page: 916
End Page: 924
Language: English
DOI: 10.1002/ijc.30791
PROVIDER: scopus
PMCID: PMC5518236
PUBMED: 28524234
DOI/URL:
Notes: Article -- Export Date: 1 August 2017 -- Source: Scopus
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MSK Authors
  1. Anne S Reiner
    122 Reiner
  2. Mark E Robson
    368 Robson
  3. Irene Orlow
    192 Orlow
  4. Marinela Capanu
    211 Capanu
  5. Jonine L Bernstein
    104 Bernstein
  6. Xiaolin Liang
    41 Liang
  7. Meghan   Woods
    13 Woods