Durable response to brentuximab vedotin plus cyclophosphamide, doxorubicin, and prednisone (BV-CHP) in a patient with CD30-positive PTCL arising as a post-transplant lymphoproliferative disorder (PTLD) Journal Article
| Authors: | Hong, J.; Johnson, W. T.; Kartan, S.; Gonsalves, A. S.; Fenkel, J. M.; Gong, J. Z.; Porcu, P. |
| Article Title: | Durable response to brentuximab vedotin plus cyclophosphamide, doxorubicin, and prednisone (BV-CHP) in a patient with CD30-positive PTCL arising as a post-transplant lymphoproliferative disorder (PTLD) |
| Abstract: | T-cell PTLDs are lymphoid proliferations that develop in recipients of SOT or allogeneic HSCT. They carry an extremely poor prognosis with a reported median survival of only 6 months. The infrequency with which they are encountered makes treatment a challenge due to the lack of prospective trials to guide management. The significantly higher risk of morbidity and mortality in T-cell PTLD, compared to B-cell PTLD, underscores the challenge of treating these patients and the need for new therapeutic options. Brentuximab vedotin, an ADC targeting CD30, is FDA-approved in combination with CHP as front-line treatment for patients with CD30 expressing PTCL. Herein we report a case of CD30-positive T-cell PTLD that was successfully treated with BV-CHP, suggesting the added value of the addition of BV to chemotherapy, contributing to our patient’s long and ongoing progression-free survival. To our knowledge, this is the first documented case of successful treatment using BV-CHP for a CD30-positive, EBV-negative, late T-cell PTLD. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
| Keywords: | immunohistochemistry; cancer chemotherapy; clinical article; aged; prednisone; fatigue; mortality; case report; doxorubicin; liver transplantation; rituximab; flow cytometry; positron emission tomography; follow up; computer assisted tomography; skin biopsy; thrombocytopenia; cyclophosphamide; deep vein thrombosis; vinblastine; dyspnea; lung embolism; b cell lymphoma; gene rearrangement; bleomycin; sepsis; perforin; immunophenotyping; thorax radiography; lymphoproliferative disease; tacrolimus; endoscopy; lymphadenopathy; cd19 antigen; night sweat; apixaban; duodenum ulcer; t-cell; peripheral t-cell lymphoma; bile duct injury; acute myeloid leukemia; ethambutol; foot pain; mycophenolate mofetil; brentuximab vedotin; cd30; human; male; article; brentuximab; post-transplant lymphoproliferative disorders; bv-chp; nos; popliteal vein |
| Journal Title: | Current Oncology |
| Volume: | 28 |
| Issue: | 6 |
| ISSN: | 1198-0052 |
| Publisher: | Multimed Inc |
| Date Published: | 2021-12-01 |
| Start Page: | 5067 |
| End Page: | 5072 |
| Language: | English |
| DOI: | 10.3390/curroncol28060426 |
| PROVIDER: | scopus |
| PMCID: | PMC8699839 |
| PUBMED: | 34940065 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 January 2022 -- Source: Scopus |
