Immunity beyond cancer cells: Perspective from tumor tissue Review
| Authors: | Gao, S.; Hsu, T. W.; Li, M. O. |
| Review Title: | Immunity beyond cancer cells: Perspective from tumor tissue |
| Abstract: | Investigation of cancer as a cell-level disease has led to the development of cancer cell-directed therapies including cytotoxic T lymphocyte (CTL)-based immunotherapy; yet, many patients are refractory to these modalities of cancer treatment and acquired resistance frequently occurs. Of note, cancer environment controls the manifestation of cancerous cell phenotype. Helper T (Th) cells orchestrate immune defense responses targeting cancer cells as well as the tumor microenvironment. Recent studies have shown that in addition to interferon (IFN)-gamma-producing Th1 cells, interleukin (IL)-4-producing Th2 cells function as potent anticancer effectors in part by promoting tumor stroma reconfiguration and tumor tissue repair. Such Th cell-mediated tissue-level immunity may be harnessed for novel modalities of cancer environment immunotherapy. |
| Keywords: | immunotherapy; microenvironment; differentiation; prostate-cancer; cells; t-cell; acquired-resistance; th2; promotes; dependent mechanism; il-17 |
| Journal Title: | Trends in Cancer |
| Volume: | 7 |
| Issue: | 11 |
| ISSN: | 2405-8025 |
| Publisher: | Cell Press |
| Date Published: | 2021-11-01 |
| Start Page: | 1010 |
| End Page: | 1019 |
| Language: | English |
| ACCESSION: | WOS:000709306500006 |
| DOI: | 10.1016/j.trecan.2021.06.007 |
| PROVIDER: | wos |
| PMCID: | PMC8541902 |
| PUBMED: | 34305041 |
| Notes: | Review -- Source: Wos |
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