Temporal dynamics of persistent germinal centers and memory B cell differentiation following respiratory virus infection Journal Article

   

Authors:	Yewdell, W. T.; Smolkin, R. M.; Belcheva, K. T.; Mendoza, A.; Michaels, A. J.; Cols, M.; Angeletti, D.; Yewdell, J. W.; Chaudhuri, J.
Article Title:	Temporal dynamics of persistent germinal centers and memory B cell differentiation following respiratory virus infection
Abstract:	Following infection or immunization, memory B cells (MBCs) and long-lived plasma cells provide humoral immunity that can last for decades. Most principles of MBC biology have been determined with hapten-protein carrier models or fluorescent protein immunizations. Here, we examine the temporal dynamics of the germinal center (GC) B cell and MBC response following mouse influenza A virus infection. We find that antiviral B cell responses within the lung-draining mediastinal lymph node (mLN) and the spleen are distinct in regard to duration, enrichment for antigen-binding cells, and class switching dynamics. While splenic GCs dissolve after 6 weeks post-infection, mLN hemagglutinin-specific (HA+) GCs can persist for 22 weeks. Persistent GCs continuously differentiate MBCs, with “peak” and “late” GCs contributing equal numbers of HA+ MBCs to the long-lived compartment. Our findings highlight critical aspects of persistent GC responses and MBC differentiation following respiratory virus infection with direct implications for developing effective vaccination strategies. © 2021 The Authors
Keywords:	germinal center; respiratory virus; influenza a virus; antiviral; memory b cell
Journal Title:	Cell Reports
Volume:	37
Issue:	6
ISSN:	2211-1247
Publisher:	Cell Press
Date Published:	2021-11-09
Start Page:	109961
Language:	English
DOI:	10.1016/j.celrep.2021.109961
PROVIDER:	scopus
PUBMED:	34758310
PMCID:	PMC7612942
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118897502&doi=10.1016%2fj.celrep.2021.109961&partnerID=40&md5=475699929882bcc875fe63f86d59c9ed
Notes:	Article -- Export Date: 1 December 2021 -- Source: Scopus

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