Cross-sectional study evaluating the seroprevalence of SARS-CoV-2 antibodies among healthcare workers and factors associated with exposure during the first wave of the COVID-19 pandemic in New York Journal Article


Authors: Bryan, A.; Tatem, K.; Diuguid-Gerber, J.; Cooke, C.; Romanoff, A.; Choudhury, N.; Scanlon, M.; Kishore, P.; Sydney, E.; Masci, J.; Bakshi, P.; Pemmasani, S.; Davis, N. J.; Maru, D.
Article Title: Cross-sectional study evaluating the seroprevalence of SARS-CoV-2 antibodies among healthcare workers and factors associated with exposure during the first wave of the COVID-19 pandemic in New York
Abstract: Objective Estimate the seroprevalence of SARS-CoV-2 antibodies among New York City Health and Hospitals (NYC H+H) healthcare workers during the first wave of the COVID-19 pandemic, and describe demographic and occupational factors associated with SARS-CoV-2 antibodies among healthcare workers. Design Descriptive, observational, cross-sectional study using a convenience sample of data from SARS-CoV-2 serological tests accompanied by a demographic and occupational survey administered to healthcare workers. Setting A large, urban public healthcare system in NYC. Participants Participants were employed by NYC H+H and either completed serological testing at NYC H+H between 30 April 2020 and 30 June 2020, or completed SARS-CoV-2 antibody testing outside of NYC H+H and were able to self-report results from the same time period. Primary outcome measure SARS-CoV-2 serostatus, stratified by key demographic and occupational characteristics reported through the demographic and occupational survey. Results Seven hundred and twenty-seven survey respondents were included in analysis. Participants had a mean age of 46 years (SD=12.19) and 543 (75%) were women. Two hundred and fourteen (29%) participants tested positive or reported testing positive for the presence of SARS-CoV-2 antibodies (IgG+). Characteristics associated with positive SARS-CoV-2 serostatus were Black race (25% IgG +vs 15% IgG-, p=0.001), having someone in the household with COVID-19 symptoms (49% IgG +vs 21% IgG-, p<0.001), or having a confirmed COVID-19 case in the household (25% IgG +vs 5% IgG-, p<0.001). Characteristics associated with negative SARS-CoV-2 serostatus included working on a COVID-19 patient floor (27% IgG +vs 36% IgG-, p=0.02), working in the intensive care unit (20% IgG +vs 28% IgG-, p=0.03), being employed in a clinical occupation (64% IgG +vs 78% IgG-, p<0.001) or having close contact with a patient with COVID-19 (51% IgG +vs 62% IgG-, p=0.03). Conclusions Results underscore the significance that community factors and inequities might have on SARS-CoV-2 exposure for healthcare workers. © 2021 Author(s). Published by BMJ.
Keywords: adult; controlled study; aged; middle aged; major clinical study; demography; risk factor; self report; intensive care unit; health care personnel; health care system; cross-sectional study; immunoassay; epidemiology; observational study; new york; serology; occupational exposure; exposure; pandemic; convenience sample; seroprevalence; human; male; female; article; black person; severe acute respiratory syndrome coronavirus 2; coronavirus disease 2019; covid-19; sars-cov-2 antibody; occupational & industrial medicine
Journal Title: BMJ Open
Volume: 11
Issue: 11
ISSN: 2044-6055
Publisher: BMJ Publishing Group Ltd.  
Date Published: 2021-11-01
Start Page: e053158
Language: English
DOI: 10.1136/bmjopen-2021-053158
PROVIDER: scopus
PMCID: PMC8572359
PUBMED: 34732494
DOI/URL:
Notes: Article -- Export Date: 1 December 2021 -- Source: Scopus
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