Protein synthesis in the tumor-influenced hepatocyte Journal Article
| Authors: | Warren, R. S.; Jeevanandam, M.; Brennan, M. F. |
| Article Title: | Protein synthesis in the tumor-influenced hepatocyte |
| Abstract: | Total body protein turnover is elevated in the Fischer 344 rat bearing a subcutaneous transplantable methylcholanthrene-induced sarcoma. To assess the contribution of the liver, we have measured protein synthesis by hepatocytes freshly isolated from tumor-bearing animals over a range of tumor burdens and from sham-inoculated nontumor bearers. Synthetic rates of total hepatocyte protein were more than twofold greater in hepatocytes from tumor-bearing animals (P < 0.005) and the increase was proportional to the tumor burden in individual animals (n = 19; r = 0.68; p < 0.005). When compared with pair-fed nontumor bearers, the differences in rates of total hepatocyte protein synthesis reached statistical significance only when the tumor burden exceeded 5% of total body weight. The stimulation in synthetic rates applied equally to secretory and nonsecretory hepatocyte protein. Furthermore, a lack of net protein accrual in the livers of tumor-bearing animals suggests a concomitant increase in the rate of hepatic protein degradation. |
| Keywords: | nonhuman; liver neoplasms; proteins; animal cell; animal; cell division; body weight; sarcoma; liver; protein synthesis; rat; rats; liver cell; disease models, animal; organ weight; rats, inbred f344; sarcoma, experimental; methylcholanthrene; 3 methylcholanthrene; male; priority journal; support, non-u.s. gov't; support, u.s. gov't, p.h.s. |
| Journal Title: | Surgery |
| Volume: | 98 |
| Issue: | 2 |
| ISSN: | 0039-6060 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1985-01-01 |
| Start Page: | 275 |
| End Page: | 282 |
| Language: | English |
| PUBMED: | 4 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |