Organ blood flow in Fischer-344 rats bearing MCA-induced sarcoma Journal Article
| Authors: | Van Leeuwen, P. A.; Bading, J. R.; Vydelingum, N. A.; Younes, R. N.; de Rooij, P.; Brennan, M. F. |
| Article Title: | Organ blood flow in Fischer-344 rats bearing MCA-induced sarcoma |
| Abstract: | Although blood flow is central to systemic metabolism, little is known about the effect of tumor on the perfusion of host tissues. This study evaluated the effects of a methylcholanthrene-induced sarcoma on blood flow to intra-abdominal organs and skeletal muscle of Fischer-344 rats anesthetized with pentobarbital sodium. Animals were studied by aortic injection of radiolabeled microspheres when the tumors reached 20% of body weight. Total-organ arterial flows in spleen, liver, small intestine, and pancreas were each increased to 50-150% in tumor bearers relative to controls (P < 0.05). Portal venous flow and flow per gram to hindlimb muscle were 60 +/- 20 and 300 +/- 100% greater, respectively, in tumor-bearing animals (P < 0.005). This study shows that tumor growth can be associated with large changes in organ flow and distribution of cardiac output. The increase in skeletal muscle flow in the tumor bearers, which lost normal tissue weight relative to pair-fed controls (P < 0.05), is in marked contrast to decreased muscle flow previously observed in simple starvation. |
| Keywords: | serum; weight-loss; cancer-patients; microspheres; reversal; tumor host; radiolabeled microspheres; peripheral tissue metabolism |
| Journal Title: | Journal of Applied Physiology |
| Volume: | 71 |
| Issue: | 5 |
| ISSN: | 8750-7587 |
| Publisher: | American Physiological Society |
| Date Published: | 1991-11-01 |
| Start Page: | 1674 |
| End Page: | 1678 |
| Language: | English |
| ACCESSION: | WOS:A1991GP82100004 |
| PROVIDER: | wos |
| PUBMED: | 1761462 |
| DOI: | 10.1152/jappl.1991.71.5.1674 |
| Notes: | Source: Wos |
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16Vydelingum -
17Bading
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