Childhood brain tumors: Current status of clinical trials in newly diagnosed and recurrent disease Journal Article
| Author: | Allen, J. C. |
| Article Title: | Childhood brain tumors: Current status of clinical trials in newly diagnosed and recurrent disease |
| Abstract: | Primary childhood brain tumors are the second most common form of childhood cancer (20 per cent) and the most common solid tumor. Their annual incidence in children under 15 years is 2.4 per 100,000; over 1200 new cases arise each year. Progress in this field of pediatric neurooncology has been comparatively slow. The traditional treatment modalities have been surgery and radiotherapy. At present, the new modality with the most promise is chemotherapy. Rather than provide a broad review of all aspects of the management of children with primary brain tumors, the authors wish to focus primarily on new information that will influence our treatment of the more common pediatric brain tumors such as medulloblastoma, cerebral high-grade gliomas, and brainstem glioma. The authors refer the reader to a recent excellent review of other important issues in this field. The problems unique to infants with primary brain tumors have also been reviewed elsewhere. |
| Keywords: | cancer chemotherapy; child; unclassified drug; hydroxyurea; prednisone; clinical trial; review; cisplatin; fluorouracil; cancer combination chemotherapy; cytarabine; methotrexate; brain tumor; computer assisted tomography; cyclophosphamide; vincristine; cancer therapy; carmustine; chlormethine; lomustine; procarbazine; childhood cancer; central nervous system; diagnosis; medulloblastoma; misonidazole; folinate calcium; astrocytoma; therapy; intravenous drug administration; nervous system; computer analysis; survey; 1 (2 chloroethyl) 3 (2,6 dioxo 3 piperidyl) 1 nitrosourea; human; priority journal; azarilquinone |
| Journal Title: | Pediatric Clinics of North America |
| Volume: | 32 |
| Issue: | 3 |
| ISSN: | 0031-3955 |
| Publisher: | W.B. Saunders Co. |
| Date Published: | 1985-06-01 |
| Start Page: | 633 |
| End Page: | 651 |
| Language: | English |
| DOI: | 10.1016/s0031-3955(16)34829-5 |
| PROVIDER: | scopus |
| PUBMED: | 3889800 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
