An update on mouse brain tumor models in cancer drug discovery Journal Article
| Authors: | Hambardzumyan, D.; Lyustikman, Y.; Holland, E. C. |
| Article Title: | An update on mouse brain tumor models in cancer drug discovery |
| Abstract: | Gliomas and medulloblastomas are the most common primary brain tumors in adults and children, respectively. Although the standard of care for gliomas may have evolved slightly over the last 50 years, the clinical outcome of this disease remains unchanged. Therefore, further research to improve the treatment modalities is urgently needed. An important step forward is the use of genetically and histologically accurate mouse glioma models that mimic the human tumors in their native microenvironment in order to fully understand the biology and mechanistic causes of this disease. Such strategy will help us to identify novel targets for therapies and use these models for preclinical testing. © 2007 Informa UK Ltd. |
| Keywords: | signal transduction; protein kinase b; allograft; hydroxyurea; clinical trial; review; erlotinib; monotherapy; nonhuman; drug targeting; temozolomide; brain tumor; glioma; antineoplastic agent; protein function; mouse; imatinib; antineoplastic activity; cancer cell culture; in vitro study; tumor xenograft; phosphatidylinositol 3 kinase; cancer model; cancer research; carcinogenesis; gene transfer; protein tyrosine kinase inhibitor; temsirolimus; disease model; imaging system; genetic engineering; medulloblastoma; blood brain barrier; cancer stem cell; gefitinib; oligodendroglioma; ras protein; immune deficiency; mammalian target of rapamycin inhibitor; cell cycle regulation; astrocytoma; everolimus; rapamycin; perifosine; drug delivery system; encapsulation; phosphatidylinositol 3 kinase inhibitor; mouse model; protein kinase b inhibitor; ap 23573; preclinical trial; rapamycin derivative |
| Journal Title: | Expert Opinion on Drug Discovery |
| Volume: | 2 |
| Issue: | 11 |
| ISSN: | 1746-0441 |
| Publisher: | Informa Healthcare |
| Date Published: | 2007-11-01 |
| Start Page: | 1435 |
| End Page: | 1451 |
| Language: | English |
| DOI: | 10.1517/17460441.2.11.1435 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 17 November 2011" - "Source: Scopus" |
