Patients at risk for AIDS-related opportunistic infections: Clinical manifestations and impaired gamma interferon production Journal Article
| Authors: | Murray, H. W.; Hillman, J. K.; Rubin, B. Y.; Kelly, C. D.; Jacobs, J. L.; Tyler, L. W.; Donelly, D. M.; Carriero, S. M.; Godbold, J. H.; Roberts, R. B. |
| Article Title: | Patients at risk for AIDS-related opportunistic infections: Clinical manifestations and impaired gamma interferon production |
| Abstract: | AMONG the numerous T-cell defects identified in patients with the acquired immunodeficiency syndrome (AIDS),1 the failure to generate gamma interferon2 seems likely for several reasons to be relevant to the immunopathogenesis of AIDS-related opportunistic infections. For example, gamma interferon is probably the key T-cell-derived lymphokine that induces macrophages and other potential host defense cells to exert enhanced antimicrobial activity against both intracellular and extracellular pathogens.3 4 5 6 7 8 9 10 In addition, gamma interferon also appears to have a pivotal regulatory role in a variety of other cellular immune reactions,11 including those involved in antigen-stimulated T-cell activation.12 13 14 15 Given this background and the earlier demonstration that. © 1985, Massachusetts Medical Society. All rights reserved. |
| Keywords: | major clinical study; t lymphocyte; risk; lymphatic system; gamma interferon; diagnosis; acquired immune deficiency syndrome; lymphadenopathy; human immunodeficiency virus 1; opportunistic infection; virus antibody; aids related complex; prognosis; human; priority journal |
| Journal Title: | New England Journal of Medicine |
| Volume: | 313 |
| Issue: | 24 |
| ISSN: | 0028-4793 |
| Publisher: | Massachusetts Medical Society |
| Date Published: | 1985-12-12 |
| Start Page: | 1504 |
| End Page: | 1510 |
| Language: | English |
| DOI: | 10.1056/nejm198512123132403 |
| PROVIDER: | scopus |
| PUBMED: | 3934537 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
