Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes Journal Article
| Authors: | Ullrich, A.; Bell, J. R.; Chen, E. Y.; Herrera, R.; Petruzzelli, L. M.; Dull, T. J.; Gray, A.; Coussens, L.; Liao, Y. C.; Tsubokawa, M.; Mason, A.; Seeburg, P. H.; Grunfeld, C.; Rosen, O. M.; Ramachandran, J. |
| Article Title: | Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes |
| Abstract: | We have deduced the entire 1,370-amino-acid sequence of the human insulin receptor precursor from a single complementary DNA clone. The precursor starts with a 27-amino-acid signal sequence, followed by the receptor α-subunit, a precursor processing enzyme cleavage site, then the β-subunit containing a single 23-amino-acid transmembrane sequence. There are sequence homologies to human epidermal growth factor receptor and the members of the src family of oncogene products. © 1985 Nature Publishing Group. |
| Keywords: | human cell; protein conformation; heredity; genes; protein kinases; epidermal growth factor receptor; membrane proteins; receptor, epidermal growth factor; protein tyrosine kinase; oncogenes; oncogene; dna; amino acid sequence; genetic engineering; rna, messenger; base sequence; protein-tyrosine kinases; radioisotope; protein structure; molecular weight; normal human; complementary dna; receptors, cell surface; insulin receptor; humans; human; priority journal; receptor, insulin |
| Journal Title: | Nature |
| Volume: | 313 |
| Issue: | 6005 |
| ISSN: | 0028-0836 |
| Publisher: | Nature Publishing Group |
| Date Published: | 1985-02-28 |
| Start Page: | 756 |
| End Page: | 761 |
| Language: | English |
| DOI: | 10.1038/313756a0 |
| PROVIDER: | scopus |
| PUBMED: | 2983222 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
