Elevated energy expenditure in hepatocytes from tumor-bearing rats Journal Article

  


Authors: Roh, M. S.; Ekman, L. G.; Jeevanandam, M.; Brennan, M. F.
Article Title: Elevated energy expenditure in hepatocytes from tumor-bearing rats
Abstract: Mechanisms for the development of cancer cachexia are not well defined. Oxygen consumption and the capacity of the host liver to metabolize lactate were studied in isolated hepatocytes from sarcoma-bearing rats (TIH) and pair-fed controls (CH). Basal oxygen consumption (without exogenous substrate) is significantly increased by 65% in the TIH as compared to the CH. The addition of a physiologic concentration of lactate stimulated oxygen consumption over the already stimulated basal state by 13% in the TIH compared to 5% in the CH. When the hepatocytes are incubated with 1.5 mM of [U-14C]lactate, glucose production, lactate oxidation, and entry of lactate carbons into nonsecretory protein are significantly increased in the TIH. Associated with this stimulation is a significant decrease in lactate incorporation into glycogen and lipid in the TIH. This study suggests that the tumor-influenced liver utilizes lactate at an increased rate and its intermediary metabolism is directed toward energy utilization rather than energy storage. The enhanced metabolic processes in the tumor-influenced liver are associated with an increased oxygen consumption which may be a contributory factor to the negative energy balance, a characteristic of cancer cachexia. © 1985.
Keywords: nonhuman; animal cell; animal; skin neoplasms; sarcoma; liver; rat; rats; cachexia; radioisotope; neoplasm transplantation; oxygen consumption; energy metabolism; rats, inbred f344; lactic acid; etiology; energy expenditure; methylcholanthrene; lactates; liver metabolism; cancer; male; priority journal
Journal Title: Journal of Surgical Research
Volume: 38
Issue: 5
ISSN: 0022-4804
Publisher: Academic Press Inc., Elsevier Science  
Date Published: 1985-05-01
Start Page: 407
End Page: 415
Language: English
DOI: 10.1016/0022-4804(85)90055-1
PROVIDER: scopus
PUBMED: 3990269
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022371160&doi=10.1016%2f0022-4804%2885%2990055-1&partnerID=40&md5=f5923f3f9c03a08a6d88a126a5db60be
Notes: Article -- Export Date: 26 October 2021 -- Source: Scopus
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MSK Authors
  1. Murray F Brennan
    1059 Brennan
  2. Malayappa Jeevanandam
    38 Jeevanandam
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