Human leukemic models of myelomonocytic development: A review of the HL-60 and U937 cell lines Journal Article


Authors: Harris, P.; Ralph, P.
Article Title: Human leukemic models of myelomonocytic development: A review of the HL-60 and U937 cell lines
Abstract: The human leukemic myeloblast HL-60 and monoblast U937 cell lines have made important contributions to the disciplines of cancer, hematology, and immunology. As sources of leukemic cells, they have been used for the study of neoplasia and therapeutics. As sources of hemic cells, they have been used for biochemical and biological analysis of regulation and differentiation in myelopoiesis. When stimulated with immunomodulatory factors, the cell lines develop properties of host-defense effector cells. They are also a source of cytokines that affect other cell types.
Keywords: human cell; cell differentiation; cancer cell culture; short survey; etiology; myeloblast; human; priority journal; blood and hemopoietic system; monoblast; leukemia model
Journal Title: Journal of Leukocyte Biology
Volume: 37
Issue: 4
ISSN: 0741-5400
Publisher: Federation of American Societies for Experimental Biology  
Date Published: 1985-04-01
Start Page: 407
End Page: 422
Language: English
DOI: 10.1002/jlb.37.4.407
PROVIDER: scopus
PUBMED: 3855947
DOI/URL:
Notes: Article -- Export Date: 26 October 2021 -- Source: Scopus
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