The effects of treatment with human β-interferon on the stimulation of thymidine uptake and DNA synthesis by colchicine in human fibroblasts Journal Article
| Authors: | Jasny, B. R.; Fried, J.; Tamm, I. |
| Article Title: | The effects of treatment with human β-interferon on the stimulation of thymidine uptake and DNA synthesis by colchicine in human fibroblasts |
| Abstract: | The marked inhibition by β-interferon (IFN) of colchicine-induced incorporation of [3H]-thymidine into DNA of human fetal lung fibroblasts reflects inhibition of uptake of labeled precursor, rather than an effect on DNA synthesis per se. The percent of cells in S phase as measured with flow cytometry was unchanged by a concentration of IFN that reduced the uptake of labeled thymidine by 50% at 30 h after treatment. © 1985, Mary Ann Liebert, Inc. All rights reserved. |
| Keywords: | human cell; drug efficacy; dna synthesis; cell cycle; dna; lung; fibroblast; fibroblasts; fetus; radioisotope; beta interferon; uridine; normal human; thymidine; in vitro; colchicine; thymidine h 3; tritium; interferon type i; respiratory system; human; priority journal; support, u.s. gov't, p.h.s.; uridine h 3 |
| Journal Title: | Journal of Interferon Research |
| Volume: | 5 |
| Issue: | 2 |
| ISSN: | 0197-8357 |
| Publisher: | Mary Ann Liebert, Inc |
| Date Published: | 1985-01-01 |
| Start Page: | 239 |
| End Page: | 246 |
| Language: | English |
| DOI: | 10.1089/jir.1985.5.239 |
| PROVIDER: | scopus |
| PUBMED: | 4009000 |
| DOI/URL: | |
| Notes: | Article -- The publisher's record lists the publication date as the Summer issue -- Export Date: 26 October 2021 -- Source: Scopus |
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