A platelet-derived immunoregulatory serum factor with T cell affinity Journal Article
| Authors: | Katz, I. R.; Hoffmann, M. K.; Zucker, M. B.; Bell, M. K.; Thorbecke, G. J. |
| Article Title: | A platelet-derived immunoregulatory serum factor with T cell affinity |
| Abstract: | A factor in mouse and human serum which enhances immune responses to SRBC and TNP-Ficoll in mice has been described. This factor completely reverses immunosuppression induced by syngeneic lymphoma (RCS) or allogeneic lymph node cells. T lymphocytes bind this factor, since the activity can be removed from serum by absorption with T cell containing spleen cells or cloned cytotoxic T lymphocytes. Furthermore, the factor is active only in the presence of mature T cells. Platelet α-granules seem to be the source of this serum factor because 1) the activity is lacking in plasma, in serum prepared in the absence of platelets, and in serum prepared from a patient lacking platelet α-granules and 2) isolated mouse or human platelets release an immunostimulatory factor with very similar properties upon incubation with thrombin. |
| Keywords: | t lymphocyte; t-lymphocytes; blood proteins; mouse; animals; mice; thrombocyte; neoplasm proteins; animal experiment; mice, inbred balb c; immunoregulation; mice, nude; glycoproteins; antibody formation; human experiment; blood platelets; sheep; lymphoma, large-cell; complement system proteins; humans; human; priority journal; antigens, t-independent; mice, inbred a; serum factor; blood and hemopoietic system |
| Journal Title: | Journal of Immunology |
| Volume: | 134 |
| Issue: | 5 |
| ISSN: | 0022-1767 |
| Publisher: | The American Association of Immunologists, Inc |
| Date Published: | 1985-05-01 |
| Start Page: | 3199 |
| End Page: | 3203 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 2858509 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
