Rhodamine 123 alters the mitochondrial ultrastructure of cultured L1210 cells Journal Article
| Authors: | Evenson, D. P.; Lee, J.; Darzynkiewicz, Z.; Melamed, M. R. |
| Article Title: | Rhodamine 123 alters the mitochondrial ultrastructure of cultured L1210 cells |
| Abstract: | Exposure of exponentially growing L1210 cells in vitro to 5-10 μg/ml of rhodamine 123 (R123) for 16-48 hr inhibits cell proliferation and induces cell arrest in the G(1A) phase of the cell cycle. The cells remain viable during the arrest and resume growth after removal of R123; extended exposure to R123 is cytotoxic. Exposure to R123 results in morphological alterations in mitochondria of all cells observed; specifically, mitochondria of R123-treated cells are characterized by a distention of the intracristal spaces and a significant increase in the number of matrix granules. Gross morphological changes of mitochondria include formation of extended organelles and the appearance of doughnut-shaped structures. |
| Keywords: | nonhuman; electron microscopy; in vitro study; ultrastructure; mitochondrion; tissue culture cell; priority journal |
| Journal Title: | Journal of Histochemistry and Cytochemistry |
| Volume: | 33 |
| Issue: | 4 |
| ISSN: | 0022-1554 |
| Publisher: | Sage Publications |
| Date Published: | 1985-04-01 |
| Start Page: | 353 |
| End Page: | 359 |
| Language: | English |
| DOI: | 10.1177/33.4.3980984 |
| PROVIDER: | scopus |
| PUBMED: | 3980984 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
