Anticarcinoma activity of rhodamine 123 against a murine renal adenocarcinoma Journal Article
| Authors: | Herr, H. W.; Huffman, J. L.; Huryk, R.; Heston, W. D.; Melamed, M. R.; Whitmore, W. F. Jr |
| Article Title: | Anticarcinoma activity of rhodamine 123 against a murine renal adenocarcinoma |
| Abstract: | The mitochondria of carcinoma cells retain the permeant cationic compound rhodamine 123 longer than the mitochondria of normal epithelial cells. The possibility of exploiting this difference in the chemotherapy of a marine renal adenocarcinoma was investigated Rhodamine 123 exhibited anticarcinoma activity in mice and this activity was potentiated by 2-deoxygtncose and methylglyoxal bis(gnanylhydrazone), a chemotherapeutic agent that is toxic to mitochondria. Prolonged retention of rhodamine 123 by renal tumor cells compared with normal renal epithelial cells was demonstrated by flow cytometry, perhaps explaining its antitumor activity. A combination of both mitochondrial toxins, rhodamine 123 and methylglyoxal bis(guanylhydrazone) produced the longest survival and had the greatest antitumor effect. © 1988, American Association for Cancer Research. All rights reserved. |
| Keywords: | nonhuman; antineoplastic agents; adenocarcinoma; mouse; animal; cytology; mice; animal experiment; antineoplastic activity; mice, inbred balb c; kidney carcinoma; kidney neoplasms; mitochondria; mitoguazone; rhodamine 123; intraperitoneal drug administration; deoxyglucose; male; rhodamines; xanthenes |
| Journal Title: | Cancer Research |
| Volume: | 48 |
| Issue: | 8 |
| ISSN: | 0008-5472 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 1988-04-15 |
| Start Page: | 2061 |
| End Page: | 2063 |
| Language: | English |
| PUBMED: | 3349477 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 6 August 2020 -- Source: Scopus |
