VAB-6 as initial treatment of patients with advanced seminoma Journal Article
| Authors: | Stanton, G. F.; Bosl, G. J.; Whitmore, W. F. Jr; Herr, H.; Sogani, P.; Morse, M.; Golbey, R. B. |
| Article Title: | VAB-6 as initial treatment of patients with advanced seminoma |
| Abstract: | Thirty patients with advanced seminoma were treated with VAB-6. Eighteen patients were previously untreated, eight had relapsed after radiation therapy, and four had persistent disease following chemotherapy and radiation therapy. Two patients had received prior high-dose cisplatin. Twenty-four (86%) of 28 evaluable patients achieved a complete remission. Four patients have relapsed. The median disease-free follow-up of patients achieving complete remission was 32 + months. VAB-6 is effective treatment for patients with advanced seminoma, and chemotherapy is recommended as the initial therapy in all patients with stage II seminoma with disease larger than 5cm, extragonadal seminoma, and stage III seminoma. |
| Keywords: | cancer chemotherapy; clinical article; cisplatin; fluorouracil; cancer combination chemotherapy; drug efficacy; methotrexate; nephrotoxicity; mucosa inflammation; nausea; vomiting; cyclophosphamide; vinblastine; gastrointestinal toxicity; kidney; dactinomycin; bleomycin; drug therapy; testis cancer; adverse drug reaction; seminoma; therapy; intravenous drug administration; bone marrow depression; intoxication; male genital system; cancer; human; priority journal; blood and hemopoietic system |
| Journal Title: | Journal of Clinical Oncology |
| Volume: | 3 |
| Issue: | 3 |
| ISSN: | 0732-183X |
| Publisher: | American Society of Clinical Oncology |
| Date Published: | 1985-03-01 |
| Start Page: | 336 |
| End Page: | 339 |
| Language: | English |
| DOI: | 10.1200/jco.1985.3.3.336 |
| PROVIDER: | scopus |
| PUBMED: | 2579214 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
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