Alternating cycles of etoposide plus cisplatin and VAB-6 in the treatment of poor-risk patients with germ cell tumors Journal Article
| Authors: | Bosl, G. J.; Geller, N. L.; Vogelzang, N. J.; Carey, R.; Auman, J.; Whitmore, W. F.; Herr, H.; Morse, M.; Sogani, P.; Chan, E. |
| Article Title: | Alternating cycles of etoposide plus cisplatin and VAB-6 in the treatment of poor-risk patients with germ cell tumors |
| Abstract: | A phase II trial of 6 months of alternating etoposide plus cisplatin (EP) and cyclophosphamide, vinblastine, actinomycin D, bleomycin, cisplatin (VAB-6) was conducted in 41 evaluable patients in an attempt to improve the treatment results in those patients considered to have 'poor-risk' germ cell tumors (GCT). Eight of 14 (57%) patients with mediastinal and retroperitoneal GCTs achieved complete remission (CR), and five (36%) remain alive and free of disease. Fourteen of 27 patients (52%) with poor-risk testicular cancer achieved CR, and ten (37%) remain alive and free of disease. Two patients with seminoma, one each with a testicular and extragonadal primary tumor, achieved durable CRs. Toxicity was tolerable, but greater than that of VAB-6 alone. The response and survival of the 39 patients with nonseminomatous tumors were found to be identical to the results of 29 patients with nonseminomatous GCTs and poor-risk characteristics who were treated with VAB-6 alone. Thus, this 6-month schedule of alternating months of chemotherapy is not recommended for patients with poor-risk GCTs. Patients with such tumors should be referred to centers conducting prospective trials, so that research seeking better therapy may continue. |
| Keywords: | clinical article; cisplatin; cancer combination chemotherapy; drug efficacy; nephrotoxicity; phase 2 clinical trial; etoposide; cyclophosphamide; vinblastine; hypomagnesemia; kidney; dactinomycin; bleomycin; drug therapy; germ cell tumor; adverse drug reaction; seminoma; therapy; intravenous drug administration; bone marrow depression; intoxication; testis nonseminoma cancer; drug comparison; male genital system; drug mixture; human; priority journal; blood and hemopoietic system |
| Journal Title: | Journal of Clinical Oncology |
| Volume: | 5 |
| Issue: | 3 |
| ISSN: | 0732-183X |
| Publisher: | American Society of Clinical Oncology |
| Date Published: | 1987-03-01 |
| Start Page: | 436 |
| End Page: | 440 |
| Language: | English |
| DOI: | 10.1200/jco.1987.5.3.436 |
| PROVIDER: | scopus |
| PUBMED: | 2434627 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 5 February 2021 -- Source: Scopus |
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