Long-term follow-up of patients with good-risk germ cell tumors treated with etoposide and cisplatin Journal Article

Authors: Xiao, H.; Mazumdar, M.; Bajorin, D. F.; Sarosdy, M.; Vlamis, V.; Spicer, J.; Ferrara, J.; Bosl, G. J.; Motzer, R. J.
Article Title: Long-term follow-up of patients with good-risk germ cell tumors treated with etoposide and cisplatin
Abstract: Purpose: To assess the durability of response and overall survival far patients with good-risk metastatic germ cell tumors (GCT) treated with four cycles of etoposide and cisplatin (EP). Patients and Methods: Two hundred fourteen patients treated with EP an two consecutive randomized trials for good-risk metastatic GCT were the subject of this retrospective study. The response to therapy, relapse and survival status, and results of salvage therapy are reported. Results: One hundred ninety-five patients (91%) achieved a complete response (CR). This included 182 patients (85%) who achieved a CR to chemotherapy alone and 13 patients (6%) who achieved a CR to chemotherapy plus surgical resection of viable GCT. Seventeen patients (9%) have relapsed from CR. The median time to relapse was 10 months, and the longest duration from treatment to relapse was 36 months in a patient who received three of four planned courses of therapy. Eight patients who either achieved an incomplete response (IR) or relapsed were rendered continuously disease-free by salvage therapy and are alive. One hundred eighty-three patients (86%) are alive at a median fallow-up of 7.6 years. Conclusion: Four cycles of EP constitute effective therapy and can be offered to patients with good-risk GCT. In patients with intermediate and poor-risk GCT, clinical trials remain a priority to identify more effective treatment.
Keywords: adolescent; adult; cancer survival; treatment outcome; disease-free survival; middle aged; survival analysis; retrospective studies; major clinical study; cancer recurrence; salvage therapy; cisplatin; cancer combination chemotherapy; antineoplastic agents; follow-up studies; etoposide; antineoplastic combined chemotherapy protocols; antineoplastic agents, phytogenic; risk; testis tumor; germ cell tumor; seminoma; germinoma; humans; prognosis; human; male; priority journal; article
Journal Title: Journal of Clinical Oncology
Volume: 15
Issue: 7
ISSN: 0732-183X
Publisher: American Society of Clinical Oncology  
Date Published: 1997-07-01
Start Page: 2553
End Page: 2558
Language: English
PUBMED: 9215824
PROVIDER: scopus
DOI: 10.1200/JCO.1997.15.7.2553
Notes: Article -- Export Date: 17 March 2017 -- Source: Scopus
Citation Impact
MSK Authors
  1. Dean Bajorin
    588 Bajorin
  2. Robert Motzer
    1047 Motzer
  3. Han Xiao
    41 Xiao
  4. Madhu Mazumdar
    127 Mazumdar
  5. George Bosl
    415 Bosl
  6. Vaia   Vlamis
    38 Vlamis