Evaluation of effects of levamisole and surgery on canine mammary cancer Journal Article
| Authors: | MacEwen, E. G.; Harvey, H. J.; Patnaik, A. K.; Mooney, S.; Hayes, A.; Kurzman, I.; Hardy, W. D. Jr |
| Article Title: | Evaluation of effects of levamisole and surgery on canine mammary cancer |
| Abstract: | Three hundred and forty-five dogs with mammary tumors were initially evaluated for study. One hundred and forty-four dogs with untreated malignant mammary tumors (136 adenocarcinomas, 5 malignant mixed, 3 sarcomas) were selected for study. All dogs were clinically staged and stratified on the basis of tumor volume and body weight. Dogs were randomized to either a radical mastectomy or simple mastectomy group, and then further randomized to a levamisole or placebo group. There was no significant difference in either survival time or cancer-free survival time between the surgery groups or between the levamisole and placebo groups. The most significant prognostic factor was tumor volume; dogs with tumors <41 cc had significantly enhanced survival time (p = 0.0007) and cancer-free survival time (p = 0.0005). © 1985 Raven Press, New York. |
| Keywords: | survival; controlled study; placebo; drug efficacy; nonhuman; combined modality therapy; neoplasms; animals; cancer immunotherapy; breast cancer; breast; mastectomy; animal model; survival time; immunotherapy; dog; dog diseases; dogs; surgery; mammary glands, animal; therapy; intravenous drug administration; mammary tumors; levamisole; cancerfree interval |
| Journal Title: | Journal of Biological Response Modifiers |
| Volume: | 4 |
| Issue: | 4 |
| ISSN: | 0732-6580 |
| Publisher: | Lippincott-Raven |
| Date Published: | 1985-08-01 |
| Start Page: | 418 |
| End Page: | 426 |
| Language: | English |
| PUBMED: | 4031952 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
