Intravenous and intramuscular pharmacokinetics of recombinant leukocyte A interferon Journal Article

  


Authors: Bornemann, L. D.; Spiegel, H. E.; Dziewanowska, Z. E.; Krown, S. E.; Colburn, W. A.
Article Title: Intravenous and intramuscular pharmacokinetics of recombinant leukocyte A interferon
Abstract: Interferon is currently being evaluated for the treatment of disseminated cancer and viral diseases. Alpha interferons have shown to be effective in the treatment of a number of malignancies. Recombinant leukocyte A interferon (rIFN-αA) is an alpha interferon produced by recombinant DNA techniques. A kinetic evaluation of rIFN-αA following intravenous and intramuscular administration has not been adequately defined. The present study was designed to evaluate the kinetics of rIFN-αA following intravenous and intramuscular administration of 3, 9 or 18×106 units to patients with disseminated cancer. A preliminary report of this study was presented at the meeting of the American Society for Clinical Pharmacology and Therapeutics in San Diego, March 1983 (1). © 1985 Springer-Verlag.
Keywords: adult; clinical article; aged; middle aged; interferon; alpha interferon; antineoplastic agent; cancer immunotherapy; kinetics; antivirus agent; virus infection; drug blood level; drug therapy; therapy; intravenous drug administration; pharmacokinetics; intramuscular drug administration; injections, intramuscular; interferon type i; cancer patients; dna, recombinant; cancer; humans; human; male; female; priority journal; recombinant alpha interferon a; i.v.-/i.m. administration; recombinant leukocyte a interferon; rifn-αa
Journal Title: European Journal of Clinical Pharmacology
Volume: 28
Issue: 4
ISSN: 0031-6970
Publisher: Springer Verlag  
Date Published: 1985-07-01
Start Page: 469
End Page: 471
Language: English
DOI: 10.1007/bf00544369
PUBMED: 4029251
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0021833935&doi=10.1007%2fBF00544369&partnerID=40&md5=9d73cecc75c142694e3bd5ec62102087
Notes: Article -- Export Date: 26 October 2021 -- Source: Scopus
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  1. Susan Krown
    156 Krown
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