| Abstract: |
A new and convenient synthesis of 1,3-dialkylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-diones from 6-allylamino- and 6-(substituted allyl)aminouracils by PdCl2-CuCl-O2-catalyzed oxidative cyclization is described. Further, l,3-dimethylpyrido[2,3-d]pyrimidine 2,4(1H,3H)-dione (4a) was prepared by the reaction of 6-allylamino-1,3-dimethyluracils (3a) with (AcO)2Pd and by the thermal cyclization of 3a. © 1985, The Pharmaceutical Society of Japan. All rights reserved. |
| Keywords: |
nonhuman; mass spectrometry; drug synthesis; nuclear magnetic resonance; theoretical study; drug identification; claisen rearrangement; uracil derivative; priority journal; oxidative cyclization; drug analysis; 1,3-dialkylpyrido-[2,3-d]pyrimidine; 6-(substituted allyl)aminouracil; fused uracil; palladium (ii) acetate; pdcl2-cucl-o2 complex; substituted allylamine; 1,3 dimethylpyrido[2,3 d]pyrimidine 2,4(1h,3h) dione; 1h,3h pyrido[2,3 d]pyrimidine 2,4 dione derivative
|
