Growth of human bone marrow in vitro Journal Article


Authors: Svet-Moldavsky, I.; Gulati, S. C.; Clarkson, B.
Article Title: Growth of human bone marrow in vitro
Abstract: Attempts were made to establish human bone marrow (HBM) culture. Cell proliferation was triggered by medium conditioned by acute myelocytic leukemic (AML) cells exposed to 12-O-tetradecanoyl-phorbol-13-acetate (TPA). A 6-15 fold multiplication of myelomonocytic cells was obtained in tissue culture from HBM cells. Proliferation of granulocyte-macrophage colony forming cells (CFC-GM) occurred up to 30-fold. The morphology of the cells and cytochemical markers were investigated at all stages of the culture. © 1985.
Keywords: acute granulocytic leukemia; pathophysiology; cytology; bone marrow cells; cells, cultured; cell division; culture medium; drug effect; pathology; cell culture; hematopoiesis; bone marrow cell; monocyte; monocytes; macrophage; macrophages; colony-stimulating factors; culture media; phorbol 13 acetate 12 myristate; tetradecanoylphorbol acetate; colony stimulating factor; leukemia, myelocytic, acute; human; article; colony stimulating factors; phorbol derivative; phorbols
Journal Title: Cell Biology International Reports
Volume: 9
Issue: 9
ISSN: 0309-1651
Publisher: Elsevier B.V.  
Date Published: 1985-09-01
Start Page: 833
End Page: 840
Language: English
DOI: 10.1016/0309-1651(85)90102-x
PUBMED: 3876165
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 26 October 2021 -- Source: Scopus
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  1. Bayard Clarkson
    220 Clarkson
  2. Subhash C. Gulati
    129 Gulati