Phase II trial of 4'-deoxydoxorubicin in patients with advanced breast cancer Journal Article
| Authors: | Leitner, S. P.; Casper, E. S.; Hakes, T. B.; Kaufman, R. J.; Winn, R. J.; Scoppetuolo, M.; Raymond, V.; Geller, N. L.; Young, C. W. |
| Article Title: | Phase II trial of 4'-deoxydoxorubicin in patients with advanced breast cancer |
| Abstract: | 4'-Deoxydoxorubicin (25 mg/m2 iv every 3 weeks) was evaluated in 20 patients with advanced breast cancer. The patients had good performance status and had not been heavily pretreated. Although all patients experienced leukopenia, no major therapeutic responses were observed. Nonhematologic toxicity was mild. Further evaluation of 4'-deoxydoxorubicin at this dose and schedule is not warranted in patients with advanced breast cancer. |
| Keywords: | adult; cancer chemotherapy; clinical article; aged; middle aged; prednisone; doxorubicin; fluorouracil; drug efficacy; methotrexate; phase 2 clinical trial; breast cancer; breast; leukopenia; nausea; thrombocytopenia; cyclophosphamide; vincristine; breast neoplasms; drug therapy; heart left ventricle ejection fraction; heart; adverse drug reaction; therapy; intravenous drug administration; hair loss; drug evaluation; humans; human; female; priority journal; esorubicin; blood and hemopoietic system |
| Journal Title: | Cancer Treatment Reports |
| Volume: | 69 |
| Issue: | 11 |
| ISSN: | 0361-5960 |
| Publisher: | National Cancer Institute |
| Date Published: | 1985-11-01 |
| Start Page: | 1319 |
| End Page: | 1320 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 4092194 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
