Clinical trial of iproplatin (cis-dichloro-trans-dihydroxy-bis-isopropylamine platinum IV, CHIP) in patients with advanced breast cancer Journal Article

  


Authors: Casper, E. S.; Smart, T. C.; Hakes, T. B.; Ochoa, M. Jr; Kaufman, R. J.
Article Title: Clinical trial of iproplatin (cis-dichloro-trans-dihydroxy-bis-isopropylamine platinum IV, CHIP) in patients with advanced breast cancer
Abstract: Twenty-five women with advanced breast cancer were treated in a phase II trial of iproplatin 275 mg/m2 administered intravenously every 4 weeks. All patients had measurable or evaluable indicator lesions, and had undergone treatment with no more than one previous chemotherapy regimen, including adjuvant chemotherapy. Two of the twenty-four evaluable patients (8%) experienced major therapeutic responses. One patient had a complete regression of pulmonary nodules lasting 18 + months; another had a partial regression of metastatic disease in the liver (4 months). The inevaluable patient was ineligible for the study because of previous radiation to the indicator lesions on her chest wall; nonetheless, she experienced a 10 month partial regression of those nodules. Myelosuppression was generally dose limiting; thrombocytopenia was more profound, but leukopenia was more prolonged. Nausea, vomiting, diarrhea, and general malaise were prominent toxicities, and led to discontinuation of therapy in 4 patients. Iproplatin has limited activity in previously treated women with advanced breast cancer. © 1988 Kluwer Academic Publishers.
Keywords: adult; cancer chemotherapy; clinical article; aged; advanced cancer; antineoplastic agents; phase 2 clinical trial; breast cancer; bone marrow; bone marrow suppression; breast neoplasms; organoplatinum compounds; clinical trials; intravenous drug administration; middle age; phase ii study; chip; human; female; priority journal; iproplatin; support, non-u.s. gov't; support, u.s. gov't, p.h.s.
Journal Title: Investigational New Drugs
Volume: 6
Issue: 2
ISSN: 0167-6997
Publisher: Springer  
Date Published: 1988-06-01
Start Page: 87
End Page: 91
Language: English
DOI: 10.1007/bf00195365
PUBMED: 3049433
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023915416&doi=10.1007%2fBF00195365&partnerID=40&md5=85aa8f8194f43538eaf82fbcaa269f13
Notes: Article -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Tracy B Smart-Curley
    70 Smart-Curley
  2. Ephraim S Casper
    108 Casper
  3. Thomas B Hakes
    115 Hakes
  4. Richard J Kaufman
    13 Kaufman
  5. Manuel Ochoa
    5 Ochoa
Related MSK Work