Phase II trial of high-dose cisplatin in patients with malignant mesothelioma Journal Article
| Authors: | Mintzer, D. M.; Kelsen, D.; Frimmer, D.; Heelan, R.; Gralla, R. |
| Article Title: | Phase II trial of high-dose cisplatin in patients with malignant mesothelioma |
| Abstract: | Twenty-five patients with advanced malignant mesothelioma were treated in a phase II trial with high-dose cisplatin (DDP). All patients had measurable or evaluable disease. Seven patients had received prior chemotherapy. DDP (120 mg/m2) with mannitol and prehydration was given every 4 weeks for two doses and then every 6 weeks. Of 24 patients evaluable for response, three had partial responses (3, 3+, and 9 months; response rate, 13%; 95% confidence limits, 4%-31%) and one had minor response. All responses occurred in previously untreated patients. High-dose DDP has modest activity in malignant mesothelioma. |
| Keywords: | cancer chemotherapy; clinical article; aged; middle aged; cisplatin; chemotherapy; neurotoxicity; nephrotoxicity; phase 2 clinical trial; peritoneal neoplasms; nausea; neuropathy; vomiting; gastrointestinal toxicity; kidney; malignant mesothelioma; mesothelioma; drug dose; drug therapy; mannitol; adverse drug reaction; therapy; pleural neoplasms; intravenous drug administration; nervous system; bone marrow depression; drug evaluation; intoxication; respiratory system; kidney diseases; cancer; humans; human; male; female; priority journal; blood and hemopoietic system |
| Journal Title: | Cancer Treatment Reports |
| Volume: | 69 |
| Issue: | 6 |
| ISSN: | 0361-5960 |
| Publisher: | National Cancer Institute |
| Date Published: | 1985-06-01 |
| Start Page: | 711 |
| End Page: | 712 |
| Language: | English |
| PUBMED: | 4040424 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
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