Phase II trial of 4'-epi-doxorubicin in advanced carcinoma of head and neck origin Journal Article
| Authors: | Magee, M. J.; Howard, J.; Bosl, G. J.; Wittes, R. E. |
| Article Title: | Phase II trial of 4'-epi-doxorubicin in advanced carcinoma of head and neck origin |
| Abstract: | Thirty-one patients with advanced head and neck cancer were treated with 4'-epidoxorubicin. Three of 25 evaluable patients with squamous cell carcinoma and two of three with minor salivary gland carcinoma had partial remissions. Four patients received cumulative doses of 680-1270 mg/m2; none developed clinical heart failure. |
| Keywords: | adult; cancer chemotherapy; clinical article; aged; squamous cell carcinoma; carcinoma, squamous cell; doxorubicin; lung toxicity; phase 2 clinical trial; mucosa inflammation; lung embolism; head and neck cancer; head and neck neoplasms; cardiotoxicity; neoplasm metastasis; epirubicin; leukocyte count; drug therapy; heart left ventricle ejection fraction; salivary gland carcinoma; heart; adverse drug reaction; mouth; therapy; intravenous drug administration; platelet count; respiratory distress syndrome; pharynx; middle age; bone marrow depression; drug evaluation; intoxication; respiratory system; heart ventricle extrasystole; cancer; human; male; female; priority journal; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; blood and hemopoietic system; peripheral vascular system |
| Journal Title: | Cancer Treatment Reports |
| Volume: | 69 |
| Issue: | 1 |
| ISSN: | 0361-5960 |
| Publisher: | National Cancer Institute |
| Date Published: | 1985-01-01 |
| Start Page: | 125 |
| End Page: | 126 |
| Language: | English |
| PUBMED: | 3855384 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
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