Postoperative fluorescence bronchoscopic surveillance in non-small cell lung cancer patients Journal Article
| Authors: | Weigel, T. L.; Kosco, P. J.; Dacic, S.; Rusch, V. W.; Ginsberg, R. J.; Luketich, J. D. |
| Article Title: | Postoperative fluorescence bronchoscopic surveillance in non-small cell lung cancer patients |
| Abstract: | Background. Second lung primaries occur at a rate of 1% to 3% per patient-year after complete resections for non-small cell lung carcinoma (NSCLC). Fluorescence bronchoscopy appears to be a sensitive tool for surveillance of the tracheobronchial tree for early neoplasias. Methods. Patients who were disease-free after complete resection of a NSCLC were entered into a fluorescence bronchoscopy surveillance program. All suspicious lesions were biopsied along with two areas of normal mucosa to serve as negative controls. Results. A total of 73 fluorescence bronchoscopies were performed after conventional bronchoscopy in 51 patients at a median of 13 months postresection. The majority (46 of 51) of patients had stage I or II NSCLC, whereas 10% (5 of 51) had stage IIIA. Three intraepithelial neoplasias and one invasive carcinoma were identified in 3 of 51 patients (6%), all current or former smokers. Of the four lesions identified, three were in the 20 patients with prior squamous cell carcinomas. No intraepithelial neoplasias were identified by white-light bronchoscopy, whereas two of three were detected by fluorescence examination. The one invasive cancer detected was apparent on both white-light and fluorescence bronchoscopic examinations. Conclusions. Surveillance with fluorescence bronchoscopy identified lesions in 6% of postoperative NSCLC patients thought to be disease-free. Patients with prior squamous cell carcinomas appear to be a population that may warrant future prospective study of postoperative fluorescence bronchoscopic surveillance. © 2001 by The Society of Thoracic Surgeons. |
| Keywords: | adult; aged; aged, 80 and over; middle aged; major clinical study; cancer recurrence; postoperative care; follow up; lung non small cell cancer; carcinoma, non-small-cell lung; lung neoplasms; fluorescence; patient monitoring; bronchoscopy; neoplasms, second primary; population surveillance; fiberoptic bronchoscopy; humans; human; male; female; priority journal; article |
| Journal Title: | Annals of Thoracic Surgery |
| Volume: | 71 |
| Issue: | 3 |
| ISSN: | 0003-4975 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2001-03-01 |
| Start Page: | 967 |
| End Page: | 970 |
| Language: | English |
| DOI: | 10.1016/s0003-4975(00)02523-6 |
| PUBMED: | 11269482 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Presented at the 36th Annual Meeting of The Society of Thoracic Surgeons; 2000 Jan 31-Feb 2; Ft Lauderdale, FL -- Export Date: 21 May 2015 -- Source: Scopus |
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