| Abstract: |
Despite burgeoning progress in HSV-1 research, particularly related to the structure and organization of the viral genome, the processes and mechanisms involved in latency and reactivation remain poorly understood. This section attempts to outline current concepts and to highlight major questions and hypotheses concerning latency and reactivation. It is hoped that such discussion will serve as a stimulus and a framework for future inquiry. Discussion is divided into three sections dealing in turn with each of the major three stages of the HSV-1 life cycle: initiation, maintenance, and reactivation of latent infection. During each of these stages, three major factors interact: the virus and its gene products, the infected host cells, and systemic antiviral defenses. The first two of these are considered immediately below, while systemic immunity is considered separately in a subsequent section. © 1985 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. |
| Keywords: |
human cell; chemotherapy; animal cell; animal; animal experiment; recurrence; herpes simplex; transcription, genetic; time factors; simplexvirus; short survey; dna, viral; virus infection; immunity; peripheral nerves; herpes simplex virus 1; therapy; peripheral nervous system; virus reactivation; human experiment; virus activation; immunization; prevention; virus dna; genes, viral; latent virus infection; human; adaptation, physiological; support, non-u.s. gov't
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