Cytokinetics of a human neuroblastoma cell line following treatment with dianhydrogalactitol Journal Article
| Authors: | Sordillo, P. P.; Andreeff, M.; Helson, L.; Steinmetz, J.; Melamed, M. R. |
| Article Title: | Cytokinetics of a human neuroblastoma cell line following treatment with dianhydrogalactitol |
| Abstract: | Studies were carried out on the effect of dianhydrogalactitol on a human neuroblastoma cell line in culture. The drug was cytotoxic at concentrations of 5 μg/ml and 10 μml for 1 hour, but not at 1 μml. Flow cytometry of DNA showed that cell kill was preceded by a transient accumulation of cells in early S at 10 hours, and in late S at 36 hours. Smaller increases in the percent of cells in S phase were seen after treatment with 1 μg/ml, without cell kill. It may be concluded that dianhydrogalactitol causes an S-phase block, followed by death of cells in late S at concentrations above 5 μg/ml. Assistant Attending Physician, Solid Tumor Service, Department of Medicine; Research Associate, Laboratory of Biophysics, Recipient, American Cancer Society Junior Faculty Clinical Award. © 1985 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. |
| Keywords: | unclassified drug; human cell; drug efficacy; flow cytometry; cell cycle; cell line; cytotoxicity; in vitro study; cell culture; neuroblastoma; dna, neoplasm; cytokinesis; nervous system; sugar alcohols; humans; human; dianhydrogalactitol; nsc 132313 |
| Journal Title: | Cancer Investigation |
| Volume: | 3 |
| Issue: | 4 |
| ISSN: | 0735-7907 |
| Publisher: | Informa Healthcare |
| Date Published: | 1985-01-01 |
| Start Page: | 321 |
| End Page: | 325 |
| Language: | English |
| DOI: | 10.3109/07357908509039794 |
| PUBMED: | 4027754 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
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