Cisplatin nephrotoxicity. Correlation with plasma platinum concentrations Journal Article
| Authors: | Kelsen, D. P.; Alcock, N.; Young, C. W. |
| Article Title: | Cisplatin nephrotoxicity. Correlation with plasma platinum concentrations |
| Abstract: | Plasma platinum concentrations were measured in 45 patients receiving 46 courses of cisplatin (DDP) 100-120 mg/m2 and in 21 patients receiving 35-60 mg/m2. Samples were drawn 5 minutes, 24, and 48 hours following completion of the DDP infusion. Nephrotoxicity was defined as a greater than 50% increase in serum creatinine measured at 24 and/or 48 hours when compared to the baseline pretreatment value. In patients receiving DDP 100-120 mg/m2, 5/20 with 5-minute plasma platinum concentrations greater than 6 μg/ml developed nephrotoxicity; 0/26 with concentrations less than 6 μg/ml became nephrotoxic (p < 0.05). Concentrations at 24 and 48 hours in toxic and nontoxic patients were similar. Five-minute plasma platinum concentrations in excess of 6 μg/ml did not occur in the 21 patients receiving DDP 35-60 mg/m2. Only one of these 21 patients became nephrotoxic. The data suggest that an increased incidence of acute nephrotoxicity is related to high peak plasma platinum concentrations. |
| Keywords: | cancer chemotherapy; clinical article; cisplatin; doxorubicin; nephrotoxicity; cyclophosphamide; vinblastine; kidney; bleomycin; drug toxicity; drug dose; drug blood level; drug therapy; vinblastine sulfate; mannitol; adverse drug reaction; therapy; intravenous drug administration; blood level; intoxication; human; priority journal; blood and hemopoietic system; platinum blood level |
| Journal Title: | American Journal of Clinical Oncology |
| Volume: | 8 |
| Issue: | 1 |
| ISSN: | 0277-3732 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1985-02-01 |
| Start Page: | 77 |
| End Page: | 80 |
| Language: | English |
| DOI: | 10.1097/00000421-198502000-00052 |
| PUBMED: | 4039530 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
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