Nonrandom chromosome alterations in rhabdomyosarcoma Journal Article
| Authors: | Trent, J.; Casper, J.; Meltzer, P.; Thompson, F.; Fogh, J. |
| Article Title: | Nonrandom chromosome alterations in rhabdomyosarcoma |
| Abstract: | Chromosome banding analysis was attempted on tumor cells from a total of six rhabdomyosarcomas. Results revealed a variety of chromosome alterations, including frequent structural rearrangement of chromosome #1 and the finding in one patient of multiple double minutes. The single chromosome most consistently involved in structural rearrangements was #3. Simple deletion or translocation of either the long or short arm of chromosome #3 was found in all rhabdomyosarcoma tumors examined in this report. Further, a review of the limited previous literature on rhabdomyosarcoma provided further support for the frequent alteration of chromosome #3 in this disease. Results from our study provide preliminary evidence that alterations of chromosome 3p14-21 may represent a site of nonrandom chromosome change in rhabdomyosarcoma. © 1985. |
| Keywords: | major clinical study; heredity; histology; translocation, genetic; chromosome aberrations; rhabdomyosarcoma; karyotyping; etiology; humans; human; priority journal; chromosome 1 aberration; chromosomes, human, 1-3; chromosome 3 aberration |
| Journal Title: | Cancer Genetics and Cytogenetics |
| Volume: | 16 |
| Issue: | 3 |
| ISSN: | 0165-4608 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 1985-04-01 |
| Start Page: | 189 |
| End Page: | 197 |
| Language: | English |
| DOI: | 10.1016/0165-4608(85)90045-7 |
| PUBMED: | 3978590 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
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