Metastatic neuroblastoma and testicular involvement Journal Article


Authors: Kushner, B. H.; Vogel, R.; Hajdu, S. I.; Helson, L.
Article Title: Metastatic neuroblastoma and testicular involvement
Abstract: Neuroblastoma metastatic to the testes is thought to be an extremely rare event and is therefore not routinely considered in the evaluation of neuroblastoma patients. A review of metastatic sites in a series of neuroblastoma patients, however, revealed 11 cases with testicular involvement. Analysis of these cases suggests that the phenomenon may not be uncommon in a subset of neuroblastoma patients, namely, male patients with infra‐diaphragmatic primaries and advanced‐stage disease. Because the testes constitute a sanctuary site for tumor cells, occult testicular involvement may play a role in the relapse of patients judged to be in complete remission. Accordingly, it is proposed that in the above group of patients special diagnostic attention should be directed at the scrotal contents and, if testicular involvement is detected, orchiectomy or local irradiation should be considered. Cancer 56: 1730‐1732, 1985. Copyright © 1985 American Cancer Society
Keywords: adolescent; child; clinical article; child, preschool; metastasis; infant; neuroblastoma; diagnosis; testis tumor; testicular neoplasms; adrenal gland neoplasms; nervous system; endocrine system; autonomic nervous system; male genital system; human; male; priority journal; testis metastasis
Journal Title: Cancer
Volume: 56
Issue: 7
ISSN: 0008-543X
Publisher: Wiley Blackwell  
Date Published: 1985-10-01
Start Page: 1730
End Page: 1732
Language: English
DOI: 10.1002/1097-0142(19851001)56:7<1730::Aid-cncr2820560744>3.0.Co;2-i
PUBMED: 44027903
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 26 October 2021 -- Source: Scopus
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  1. Brian Kushner
    311 Kushner
  2. Steven I. Hajdu
    80 Hajdu
  3. Lawrence Helson
    26 Helson