Human interferon alpha in malignant lymphoma and Hodgkin's disease: Results of the American Cancer Society trial Journal Article
| Authors: | Horning, S. J.; Merigan, T. C.; Krown, S. E.; Gutterman, J. U.; Louie, A.; Gallagher, J.; McCravey, J.; Abramson, J.; Cabanillas, F.; Oettgen, H.; Rosenberg, S. A. |
| Article Title: | Human interferon alpha in malignant lymphoma and Hodgkin's disease: Results of the American Cancer Society trial |
| Abstract: | Forty‐nine patients with non‐Hodgkin's lymphoma or Hodgkin's disease were entered into a multi‐institutional phase II trial to evaluate the antitumor activity of human interferon alpha, prepared from buffy coats. Interferon alpha was administered intramuscularly in doses of 1 × 106 u, 3 × 106 u or 9 × 106 u daily for 30 days. Objective partial responses were seen in 3 of 18 patients with nodular lymphoma, all at the 9 × 106 u dose. Interferon alpha was not observed to be of therapeutic benefit in the other subtypes of non‐Hodgkin's lymphoma or Hodgkin's disease. The major toxicities consisted of fatigue, fever, myalgias and weight loss. Serum interferon levels obtained 3 to 4 hours after injection varied widely, even among patients treated at the same dose level. Despite the relatively low doses of interferon used and the brief period of administration, this study extends the earlier observations of the antitumor effect of interferon in nodular lymphoma. These results are discussed in relation to the cumulative experience in human lymphoma using alpha interferons induced in human leukocytes and those produced in bacteria by recombinant DNA techniques. Copyright © 1985 American Cancer Society |
| Keywords: | adolescent; adult; aged; middle aged; acute granulocytic leukemia; major clinical study; prednisone; fatigue; drug efficacy; alpha interferon; cancer immunotherapy; phase 2 clinical trial; leukopenia; thrombocytopenia; myalgia; body weight; hodgkin disease; fever; lymphatic system; leukemogenesis; lymphoma; drug blood level; evaluation studies; drug therapy; adverse drug reaction; therapy; intramuscular drug administration; interferon type i; chemical carcinogenesis; humans; human; male; female; priority journal; blood and hemopoietic system; nodular lymphomatosis |
| Journal Title: | Cancer |
| Volume: | 56 |
| Issue: | 6 |
| ISSN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 1985-09-15 |
| Start Page: | 1305 |
| End Page: | 1310 |
| Language: | English |
| DOI: | 10.1002/1097-0142(19850915)56:6<1305::Aid-cncr2820560614>3.0.Co;2-n |
| PUBMED: | 4027869 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
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