Interleukin 2: A review Journal Article
| Authors: | Kolitz, J. E.; Welte, K.; Sykora, K. W.; Mertelsmann, R. |
| Article Title: | Interleukin 2: A review |
| Abstract: | Interleukin 2 (IL 2) is a central mediator of the growth and functional activity of B- and T-cells, and cytotoxic cells, including natural killer and lymphokine activated killer cells. Significant defects in the production of, and response to, IL 2 have been described in a variety of congenital and acquired immunodeficiency states. IL 2 has demonstrated major anti-tumor activity in animal models. The biochemistry and molecular biology of IL 2 and its gene are reviewed, along with data regarding the IL 2 receptor, normal T-cell activation, abnormalities in IL 2 production and response in immunodeficiency states and leukemia, and initial explorations of IL 2 in the treatment of human cancer. |
| Keywords: | leukemia; review; interferon; antineoplastic agent; neoplasms; t lymphocyte; t-lymphocytes; animal; interleukin 2; liver toxicity; membrane proteins; cyclophosphamide; cytotoxicity; b lymphocyte; chill; fever; lymphatic system; malaise; lymphocyte activation; antibodies, monoclonal; amino acid sequence; immunotherapy; kinetics; drug mechanism; rna, messenger; dactinomycin; natural killer cell; acquired immunodeficiency syndrome; radioisotope; molecular biology; immune deficiency; mitomycin; biochemistry; clone cells; adverse drug reaction; therapy; interleukin-2; oligonucleotides; receptors, immunologic; thymidine h 3; phorbol 13 acetate 12 myristate; survey; receptors, interleukin-2; intoxication; cycloheximide; phytohemagglutinin; human; priority journal; dna restriction enzymes; lymphokine; calcimycin; interleukin 2 h 3 |
| Journal Title: | Arzneimittel-Forschung |
| Volume: | 35 |
| Issue: | 2 |
| ISSN: | 0004-4172 |
| Publisher: | Georg Thieme Verlag |
| Date Published: | 1985-10-01 |
| Start Page: | 1607 |
| End Page: | 1615 |
| Language: | English |
| PUBMED: | 3000391 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 26 October 2021 -- Source: Scopus |
