Anomalous glucose and insulin responses in patients with insulinoma: Caveats for diagnosis Journal Article
| Authors: | Dons, R. F.; Hodge, J.; Ginsberg, B. H.; Brennan, M. F.; Cryer, P. E.; Kourides, I. A.; Gorden, P. |
| Article Title: | Anomalous glucose and insulin responses in patients with insulinoma: Caveats for diagnosis |
| Abstract: | Two patients with insulinomas had unusual glucose and insulin-secretory dynamics in response to prolonged fasting. In patient 1, low insulin values persisted throughout three separate supervised fasts without a steady rise in the insulin-glucose ratio. In patient 2, a rising insulin-glucose ratio during a fast returned to normal after a documented catecholamine surge following a transient hypoglycemic episode. While patient 1 had clearly elevated proinsulin values of 52% to 57%, patient 2 had a near-normal value of 23%. The diagnosis of an insulinoma can usually be made by obtaining simultaneous glucose and insulin values during a prolonged supervised fast. Rarely, however, anomalous results may be obtained during supervised fasts of patients with insulinoma, and a broader range of diagnostic tests will be required to establish the correct diagnosis. © 1985, American Medical Association. All rights reserved. |
| Keywords: | aged; middle aged; prednisone; case report; pancreatic neoplasms; diagnosis; insulin; hypoglycemia; glucose; blood glucose; drug monitoring; drug blood level; leucine; catecholamines; fasting; insulinoma; endocrine system; adenoma, islet cell; diazoxide; caloric restriction; humans; human; female; priority journal; tolbutamide |
| Journal Title: | Archives of Internal Medicine |
| Volume: | 145 |
| Issue: | 10 |
| ISSN: | 0003-9926 |
| Publisher: | American Medical Association |
| Date Published: | 1985-10-01 |
| Start Page: | 1861 |
| End Page: | 1863 |
| Language: | English |
| DOI: | 10.1001/archinte.1985.00360100127021 |
| PUBMED: | 2994586 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
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