The natural history of Kaposi's sarcoma in the acquired immunodeficiency syndrome Journal Article

  


Authors: Safai, B.; Johnson, K. G.; Myskowski, P. L.; Koziner, B.; Yang, S. Y.; Cunningham-Rundles, S.; Godbold, J. H.; Dupont, B.
Article Title: The natural history of Kaposi's sarcoma in the acquired immunodeficiency syndrome
Abstract: Kaposi's sarcoma is a multifocal system neoplasm histologically characterized by proliferating fibroblastic and microvascular elements. Initial signs include macules, papules, or nodules on the skin or mucosal surface. Lesions are frequently found on the trunk, arms, and head and neck. In general, sites of involvement and tumor load do not correlate with prognosis. A general decrease in the functional capacities of T and B cells is found in most patients. Kaposi's sarcoma is reported as the initial manifestation of the acquired immunodeficiency syndrome (AIDS) in approximately 30% of cases. Most cases are in men, although it has been reported in all risk groups. Kaposi's sarcoma in AIDS is more frequent among whites and homosexuals than blacks and itnravenous drug abusers. Overall mortality is approximately 41%, with over 60% of patients alive at 1 year and 50% at 22 months. Overall survival is 18 months; however, some patients who have had the disease for 3 to 4 years are still doing well.
Keywords: survival; histopathology; mortality; review; t lymphocyte; b lymphocyte; history; homosexuality; acquired immune deficiency syndrome; kaposi sarcoma; epidemiology; drug use; intravenous drug administration; human; priority journal
Journal Title: Annals of Internal Medicine
Volume: 103
Issue: 5
ISSN: 0003-4819
Publisher: American College of Physicians  
Date Published: 1985-11-01
Start Page: 744
End Page: 750
Language: English
DOI: 10.7326/0003-4819-103-5-744
PROVIDER: scopus
PUBMED: 3901851
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022413772&doi=10.7326%2f0003-4819-103-5-744&partnerID=40&md5=907f1bbfbdd4545954c399489d0dcc40
Notes: Review -- Export Date: 26 October 2021 -- Source: Scopus
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MSK Authors
  1. Soo Y Yang
    108 Yang
  2. Patricia Myskowski
    216 Myskowski
  3. Bo Dupont
    264 Dupont
  4. Bijan Safai
    52 Safai
  5. Benjamin Koziner
    52 Koziner
  6. Susanna Cunningham-Rundles
    20 Cunningham-Rundles
  7. James Godbold
    16 Godbold
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