Treatment of Kaposi's sarcoma and thrombocytopenia with vincristine in patients with the acquired immunodeficiency syndrome Journal Article
| Authors: | Mintzer, D. M.; Real, F. X.; Jovino, L.; Krown, S. E. |
| Article Title: | Treatment of Kaposi's sarcoma and thrombocytopenia with vincristine in patients with the acquired immunodeficiency syndrome |
| Abstract: | Kaposi's sarcoma occurs in about one third of patients with the acquired immunodeficiency syndrome. Although in some patients the tumor is principally a cosmetic problem, other patients have progressive disease with significant morbidity. Twenty-three patients with Kaposi's sarcoma related to the acquired immunodeficiency syndrome were treated with vincristine. Three patients had a coexisting immune thrombocytopenia. Of the 18 patients evaluable for response, 11 had a partial response and 7 had a minor response. The median duration of partial response was 4+months. All 3 thrombocytopenic patients developed a significant increase in platelet count, which in 2 was sustained with continued treatment for 6 and 9 months, respectively. We conclude that vincristine has antitumor activity in the epidemic form of Kaposi's sarcoma and that it is also effective in the treatment of associated immune thrombocytopenia. |
| Keywords: | clinical article; alpha interferon; neurotoxicity; antineoplastic agent; neuropathy; thrombocytopenia; vincristine; response; acquired immune deficiency syndrome; kaposi sarcoma; drug therapy; adverse drug reaction; therapy; intravenous drug administration; nervous system; intoxication; human; priority journal; blood and hemopoietic system |
| Journal Title: | Annals of Internal Medicine |
| Volume: | 102 |
| Issue: | 2 |
| ISSN: | 0003-4819 |
| Publisher: | American College of Physicians |
| Date Published: | 1985-02-01 |
| Start Page: | 200 |
| End Page: | 202 |
| Language: | English |
| DOI: | 10.7326/0003-4819-102-2-200 |
| PROVIDER: | scopus |
| PUBMED: | 2981498 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
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