Chemotherapy of metastatic sweat gland carcinoma. A retrospective review Journal Article

  


Authors: Coonley, C. J.; Kelsen, D. P.; Huvos, A. G.; Schauer, P.; Sordillo, P.
Article Title: Chemotherapy of metastatic sweat gland carcinoma. A retrospective review
Abstract: Sweat gland carcinoma (SGC) is a rare malignancy of the skin. though many patients with SGC die of disseminated metastases, little is known regarding the value of systemic chemotherapy for this disease. We reviewed the records of 20 patients with metastatic SGC who were treated with chemotherapy at Memorial Hospital between 1968 and 1983. A large variety of drugs were given. Although only a few patients were treated with any given regimen, metastatic SGC appears to be poorly responsive to a wide variety of chemotherapeutic regimens. Five major responses were observed in 30 chemotherapy trials performed in 17 patients with measurable/evaluable disease. No patient responded to single agent therapy alone. In this small group of patients, SGC appears to be a relatively chemotherapy resistant tumor. Larger, group-wide or inter-group trials are needed to prospectively evaluate the use of chemotherapy in this disease. Doxorubicin and cyclophosphamide, the two drugs used most commonly in those combinations where responses were seen, appear to be reasonable choices of initial treatment of patients with metastatic disease. Our review does not provide data to support the empiric use of chemotherapy in an adjuvant setting.
Keywords: clinical article; prednisone; cisplatin; doxorubicin; fluorouracil; cancer combination chemotherapy; drug efficacy; chemotherapy; metastasis; cyclophosphamide; vincristine; dactinomycin; bleomycin; drug therapy; adverse drug reaction; therapy; intravenous drug administration; sweat gland carcinoma; bone marrow depression; human; priority journal; blood and hemopoietic system
Journal Title: American Journal of Clinical Oncology
Volume: 8
Issue: 4
ISSN: 0277-3732
Publisher: Lippincott Williams & Wilkins  
Date Published: 1985-08-01
Start Page: 307
End Page: 311
Language: English
DOI: 10.1097/00000421-198508000-00006
PUBMED: 3909802
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022402040&doi=10.1097%2f00000421-198508000-00006&partnerID=40&md5=5344a029b6330fd22b068d0a60ae49ca
Notes: Article -- Export Date: 26 October 2021 -- Source: Scopus
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MSK Authors
  1. David P Kelsen
    537 Kelsen
  2. Andrew G Huvos
    289 Huvos
  3. Peter P. Sordillo
    20 Sordillo
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