Authors: | Manning-Geist, B. L.; Gatius, S.; Liu, Y.; Gil, M.; Da Cruz Paula, A.; Tuset, N.; Abu-Rustum, N. R.; Aghajanian, C.; Weigelt, B.; Matias-Guiu, X. |
Article Title: | Diagnosis and management of an endometrial cancer patient with Cowden syndrome |
Abstract: | Somatic PTEN alterations are common in endometrial carcinoma (EC), but in rare cases PTEN mutations are associated with inherited syndromes. Here, we present a case of Cowden syndrome-associated EC. We discuss clinical, pathologic and molecular features of her tumor and PTEN-mutated EC, inherited syndromes predisposing to EC and PTEN-targeted therapies. © 2021 Elsevier Inc. |
Keywords: | germline; pathology; targeted therapy; cowden syndrome; pten mutation |
Journal Title: | Gynecologic Oncology |
Volume: | 163 |
Issue: | 1 |
ISSN: | 0090-8258 |
Publisher: | Elsevier Inc. |
Date Published: | 2021-10-01 |
Start Page: | 14 |
End Page: | 21 |
Language: | English |
PMCID: | PMC8515352 |
DOI: | 10.1016/j.ygyno.2021.08.008 |
PROVIDER: | scopus |
PUBMED: | 34446268 |
DOI/URL: | |
Notes: | Article -- Source: Scopus |