Diagnosis and management of an endometrial cancer patient with Cowden syndrome Journal Article


Authors: Manning-Geist, B. L.; Gatius, S.; Liu, Y.; Gil, M.; Da Cruz Paula, A.; Tuset, N.; Abu-Rustum, N. R.; Aghajanian, C.; Weigelt, B.; Matias-Guiu, X.
Article Title: Diagnosis and management of an endometrial cancer patient with Cowden syndrome
Abstract: Somatic PTEN alterations are common in endometrial carcinoma (EC), but in rare cases PTEN mutations are associated with inherited syndromes. Here, we present a case of Cowden syndrome-associated EC. We discuss clinical, pathologic and molecular features of her tumor and PTEN-mutated EC, inherited syndromes predisposing to EC and PTEN-targeted therapies. © 2021 Elsevier Inc.
Keywords: germline; pathology; targeted therapy; cowden syndrome; pten mutation
Journal Title: Gynecologic Oncology
Volume: 163
Issue: 1
ISSN: 0090-8258
Publisher: Elsevier Inc.  
Date Published: 2021-10-01
Start Page: 14
End Page: 21
Language: English
PMCID: PMC8515352
DOI: 10.1016/j.ygyno.2021.08.008
PROVIDER: scopus
PUBMED: 34446268
DOI/URL:
Notes: Article -- Source: Scopus
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
  1. Britta Weigelt
    633 Weigelt
  2. Ying Liu
    105 Liu