Diagnosis and management of an endometrial cancer patient with Cowden syndrome Journal Article

   


Authors: Manning-Geist, B. L.; Gatius, S.; Liu, Y.; Gil, M.; Da Cruz Paula, A.; Tuset, N.; Abu-Rustum, N. R.; Aghajanian, C.; Weigelt, B.; Matias-Guiu, X.
Article Title: Diagnosis and management of an endometrial cancer patient with Cowden syndrome
Abstract: Somatic PTEN alterations are common in endometrial carcinoma (EC), but in rare cases PTEN mutations are associated with inherited syndromes. Here, we present a case of Cowden syndrome-associated EC. We discuss clinical, pathologic and molecular features of her tumor and PTEN-mutated EC, inherited syndromes predisposing to EC and PTEN-targeted therapies. © 2021 Elsevier Inc.
Keywords: germline; pathology; targeted therapy; cowden syndrome; pten mutation
Journal Title: Gynecologic Oncology
Volume: 163
Issue: 1
ISSN: 0090-8258
Publisher: Elsevier Inc.  
Date Published: 2021-10-01
Start Page: 14
End Page: 21
Language: English
PMCID: PMC8515352
DOI: 10.1016/j.ygyno.2021.08.008
PROVIDER: scopus
PUBMED: 34446268
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113384193&doi=10.1016%2fj.ygyno.2021.08.008&partnerID=40&md5=f594f691b8ea6bb63e84151902d5f121
Notes: Article -- Source: Scopus
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MSK Authors
  1. Nadeem Abu-Rustum
    888 Abu-Rustum
  2. Carol A Aghajanian
    609 Aghajanian
  3. Britta Weigelt
    633 Weigelt
  4. Arnaud Fabian Da Cruz Paula
    145 Da Cruz Paula
  5. Ying Liu
    105 Liu
  6. Beryl Manning-Geist
    51 Manning-Geist
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