HPV-associated oropharyngeal cancer de-escalation strategies and trials: Past failures and future promise Review
| Authors: | Zakeri, K.; Dunn, L.; Lee, N. |
| Review Title: | HPV-associated oropharyngeal cancer de-escalation strategies and trials: Past failures and future promise |
| Abstract: | HPV-associated oropharynx squamous cell carcinomas are radiosensitive and chemosensitive, thus, portending a favorable prognosis. Treatment de-intensification strategies aim to reduce toxicity while maintaining efficacy. Although approaches that have substituted cisplatin with cetuximab or omitted chemotherapy have not been successful, Transoral Robotic Surgery with de-intensified adjuvant therapy has been promising. Additionally, personalized approaches are taking advantage of tumor biology and utilizing tumor reduction or hypoxia on imaging as a predictive marker to successfully de-escalate radiotherapy and chemotherapy. © 2021 Wiley Periodicals LLC |
| Keywords: | oropharynx cancer; treatment de-escalation; hpv-associated |
| Journal Title: | Journal of Surgical Oncology |
| Volume: | 124 |
| Issue: | 6 |
| ISSN: | 0022-4790 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2021-11-01 |
| Start Page: | 962 |
| End Page: | 966 |
| Language: | English |
| DOI: | 10.1002/jso.26696 |
| PROVIDER: | scopus |
| PUBMED: | 34595766 |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
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