Immunotherapy with monoclonal antibodies in metastatic melanoma Journal Article
| Authors: | Steffens, T. A.; Bajorin, D. F.; Houghton, A. N. |
| Article Title: | Immunotherapy with monoclonal antibodies in metastatic melanoma |
| Abstract: | Therapy for metastatic melanoma has been disappointing to date. Treatment with chemotherapy only uncommonly results in complete responses and rarely results in long-term survivors. The identification of human melanoma cell surface antigens has led to the development of an array of mouse monoclonal antibodies (MAb) for use in the diagnosis and therapy of patients with metastatic melanoma. Strategies utilizing MAbs based on immunologic approaches have been developed. Naked MAbs directed against glycoprotein surface antigens or conjugated to toxins or radionuclides have shown little biologic or clinical activity. However, phase I studies of MAb directed against glycolipid antigens have yielded objective tumor shrinkage with occasional complete responses. Severe toxicity has been seen infrequently. Possible anti-tumor mechanisms include complement activation and antibody-dependent cellular cytotoxicity utilizing natural killer cells or monocytes as effector cells. Strategies to enhance the anti-tumor effects of MAb, including combinations with cytotoxic agents and cytokines, have been introduced with limited success thus far. The development of a human IgG anti-mouse antibody has been seen in nearly all treated patients. A new generation of MAb engineered to overcome the immunogenicity of mouse MAb and to enhance immune effector function will soon enter clinical trials. © 1992 the Société Internationale de Chirurgie. |
| Keywords: | review; cisplatin; cytotoxic agent; disseminated cancer; hypertension; skin toxicity; alpha interferon; interleukin 2; cancer immunotherapy; melanoma; antineoplastic activity; monoclonal antibody; gastrointestinal toxicity; antibodies, monoclonal; melanoma antigen; radioisotope; antibodies, neoplasm; immunoglobulin g antibody; ganglioside gd3; intravenous drug administration; colony stimulating factor 1; transferrin; antibody dependent cellular cytotoxicity; complement dependent cytotoxicity; glycolipid; gangliosides; ganglioside; immunotoxin; ricin; serum sickness; monoclonal antibody in 111; human; monoclonal antibody tc 99m; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; monoclonal antibody i 131 |
| Journal Title: | World Journal of Surgery |
| Volume: | 16 |
| Issue: | 2 |
| ISSN: | 0364-2313 |
| Publisher: | Springer |
| Date Published: | 1992-03-01 |
| Start Page: | 261 |
| End Page: | 269 |
| Language: | English |
| DOI: | 10.1007/bf02071530 |
| PUBMED: | 1561808 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
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