The effects of commensal microbiota on immune cell subsets and inflammatory responses Journal Article
| Authors: | Chinen, T.; Rudensky, A. Y. |
| Article Title: | The effects of commensal microbiota on immune cell subsets and inflammatory responses |
| Abstract: | Billions of years of coevolution shaped the mutually beneficial relationships between metazoans and symbiotic commensal microorganisms. Commensal microorganisms profoundly affect the physiology of the host and provide the host with survival advantages in several ways, while they could also trigger pathogenic immune responses and threaten the well-being of the host. Recent advances in DNA sequencing technology enabled the analysis of commensal microbiota, and improvements in the techniques of culturing gut-resident microorganisms and of rearing gnotobiotic rodents have made it possible to assess the effect of individual component of microbial communities on host physiology. In this review, we discuss the current understanding of the interactions of commensal microbiota with the host immune system. © 2011 John Wiley & Sons A/S. |
| Keywords: | antibiotic agent; review; nonhuman; transcription factor foxp3; lymphocyte proliferation; interleukin 2; stat3 protein; dendritic cell; interleukin 10; inflammation; bacterial strain; immunoregulation; lymphocyte differentiation; regulatory t lymphocyte; th2 cell; escherichia coli; cd4+ t lymphocyte; interleukin 6; transforming growth factor beta1; colitis; enteritis; cytokine production; th17 cell; th1 cell; bacterial colonization; vancomycin resistant enterococcus; intestine flora; macrophage; cytokine release; clostridium difficile; toll like receptor 2; immunocompetent cell; regulatory t cells; giardia lamblia; commensal; interleukin 23; peptic ulcer; bacterial polysaccharide; microbial community; interleukin 27; pattern recognition receptor; commensal microbiota; gnotobiotic mice; th17; dextran sulfate; interleukin 1 receptor associated kinase 1; retinal dehydrogenase; serum amyloid a; bacteroides vulgatus; entamoeba histolytica; enterococcus faecalis; gnotobiotics; helicobacter hepaticus; recombinant dna technology; symbiont |
| Journal Title: | Immunological Reviews |
| Volume: | 245 |
| Issue: | 1 |
| ISSN: | 0105-2896 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2012-01-01 |
| Start Page: | 45 |
| End Page: | 55 |
| Language: | English |
| DOI: | 10.1111/j.1600-065X.2011.01083.x |
| PROVIDER: | scopus |
| PUBMED: | 22168413 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 1 February 2012" - "CODEN: IMRED" - "Source: Scopus" |
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