Health-related quality of life and pain with selinexor in patients with advanced dedifferentiated liposarcoma Journal Article
| Authors: | Gounder, M.; Abdul Razak, A. R.; Gilligan, A. M.; Leong, H.; Ma, X.; Somaiah, N.; Chawla, S. P.; Martin-Broto, J.; Grignani, G.; Schuetze, S. M.; Vincenzi, B.; Wagner, A. J.; Chmielowski, B.; Jones, R. L.; Shah, J.; Shacham, S.; Kauffman, M.; Riedel, R. F.; Attia, S. |
| Article Title: | Health-related quality of life and pain with selinexor in patients with advanced dedifferentiated liposarcoma |
| Abstract: | Objective: Compare health-related quality of life (HRQoL) of selinexor versus placebo in patients with dedifferentiated liposarcoma. Materials and methods: HRQoL was assessed at baseline and day 1 of each cycle using the European Organization for Research and Treatment of Cancer 30-item core quality of life questionnaire. Results were reported from baseline to day 169 (where exposure to treatment was maximized while maintaining adequate sample size). Results: Pain scores worsened for placebo versus selinexor across all postbaseline visits, although differences in HRQoL at some visits were not significant. Other domains did not exhibit significant differences between arms; however, scores in both arms deteriorated over time. Conclusion: Patients treated with selinexor reported lower rates and slower worsening of pain compared with patients who received placebo. © 2021 Karyopharm Therapeutics. |
| Keywords: | adult; treatment outcome; aged; middle aged; young adult; major clinical study; overall survival; placebo; low drug dose; progression free survival; quality of life; multiple cycle treatment; pain; tumor volume; dexamethasone; cancer pain; health status; patient-reported outcomes; pain assessment; physical capacity; sample size; progression-free survival; dedifferentiated liposarcoma; very elderly; human; male; female; article; selinexor; european organization for research and treatment of cancer quality of life questionnaire core 30; advanced liposarcoma; selective inhibitor of nuclear export |
| Journal Title: | Future Oncology |
| Volume: | 17 |
| Issue: | 22 |
| ISSN: | 1479-6694 |
| Publisher: | Future Medicine |
| Date Published: | 2021-08-01 |
| Start Page: | 2923 |
| End Page: | 2939 |
| Language: | English |
| DOI: | 10.2217/fon-2021-0284 |
| PUBMED: | 33855868 |
| PROVIDER: | scopus |
| PMCID: | PMC9344436 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 September 2021 -- Source: Scopus |
