Evaluation of HLA‐haplotype disparate parental marrow grafts depleted of T lymphocytes by differential agglutination with a soybean lectin and E‐rosette depletion for the treatment of severe combined immunodeficiency Journal Article

  

Authors:	O'Reilly, R. J.; Brochstein, J.; Collins, N.; Keever, C.; Kapoor, N.; Kirkpatrick, D.; Kernan, N.; Dupont, B.; Burns, J.; Reisner, Y.
Article Title:	Evaluation of HLA‐haplotype disparate parental marrow grafts depleted of T lymphocytes by differential agglutination with a soybean lectin and E‐rosette depletion for the treatment of severe combined immunodeficiency
Abstract:	Abstract. The factors that impact upon successful bone marrow transplantation leading to immunologic reconstitution in severe combined immune deficiency (SCID), Wiskott‐Aldrich syndrome, and in other lethal congenital immunodeficiencies are reviewed. Evidence is presented that graft‐versus‐host disease (GVHD) can be abrogated by the depletion of T cells, even from histoincompatible marrow grafts. However, graft resistance or restricted immune reconstitution has been observed with significant frequency. The bases for T cell reconstitution and limitations in B cell humoral immune recovery in the postgrafting period are reviewed, together with emerging evidence that pretransplant cytoreduction might obviate some of these problems. © 1986 S. Karger AG, Basel
Keywords:	child; clinical article; unclassified drug; drug efficacy; combined modality therapy; t-lymphocytes; bone marrow cells; bone marrow; haplotypes; cyclophosphamide; lymphatic system; graft versus host reaction; killer cells, natural; rosette formation; graft survival; drug therapy; bone marrow transplantation; graft vs host disease; drug sensitivity; adverse drug reaction; combined immunodeficiency; immunologic deficiency syndromes; therapy; hla antigens; lymphocyte depletion; intravenous drug administration; parents; hla system; histocompatibility testing; wiskott aldrich syndrome; lectins; wiskott-aldrich syndrome; plant lectins; soybean proteins; humans; human; priority journal; article; soybean lectin; blood and hemopoietic system; agglutination tests
Journal Title:	Vox Sanguinis
Volume:	51
Issue:	Suppl. 2
ISSN:	0042-9007
Publisher:	Blackwell Publishing
Date Published:	1986-09-01
Start Page:	81
End Page:	86
Language:	English
DOI:	10.1111/j.1423-0410.1986.tb02013.x
PUBMED:	3532540
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022470022&doi=10.1111%2fj.1423-0410.1986.tb02013.x&partnerID=40&md5=6f16a67299f09b66e313c7c37e0ca7c5
Notes:	Article -- Export Date: 18 August 2021 -- Source: Scopus

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