Spinal opioid analgesics and local anesthetics in the management of chronic cancer pain Journal Article
| Authors: | Moulin, D. E.; Coyle, N. |
| Article Title: | Spinal opioid analgesics and local anesthetics in the management of chronic cancer pain |
| Abstract: | Spinal administration of opioid drugs and local anesthetics has been developed as an alternative method of pain control in the cancer population. This review addresses the indications for these techniques, choice of drugs, benefits and liabilities of the epidural v intrathecal route, efficacy in those with cancer pain, and risk of significant side effects. The need for applied pharmacokinetic principles in the use of these methods and the clinical controversies yet to be resolved are emphasized. © 1986, Board of Regents, University of Wisconsin System. All rights reserved. |
| Keywords: | drug efficacy; patient selection; neurotoxicity; pain; pharmacodynamics; nausea; vomiting; opiate; cancer pain; central nervous system; pruritus; gastrointestinal toxicity; narcotic analgesic agent; drug mechanism; short survey; methadone; morphine; respiration depression; lidocaine; bupivacaine; analgesia; epidural anesthesia; urine retention; drug tolerance; meningitis; adverse drug reaction; urinary tract; pharmacokinetics; pharmacology; naloxone; local anesthetic agent; bladder; nervous system; pharmacokinetic; intoxication; respiratory system; spinal anesthesia; local anesthetics; cancer; human; enkephalin[2 dextro alanine 5 dextro leucine]; intrathecal drug administration; metrizamide; spinal opiates; spinal cord hemorrhage |
| Journal Title: | Journal of Pain and Symptom Management |
| Volume: | 1 |
| Issue: | 2 |
| ISSN: | 0885-3924 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1986-01-01 |
| Start Page: | 79 |
| End Page: | 86 |
| Language: | English |
| DOI: | 10.1016/s0885-3924(86)80002-1 |
| PUBMED: | 2877036 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- The PDF lists the publication date as Spring -- Export Date: 18 August 2021 -- Source: Scopus |
