L3T4(+), B2A2(+) thymocytes from infant mice produce IL 2 after interaction with accessory cells expressing self class II antigens Journal Article
| Authors: | Lattime, E. C.; Stutman, O. |
| Article Title: | L3T4(+), B2A2(+) thymocytes from infant mice produce IL 2 after interaction with accessory cells expressing self class II antigens |
| Abstract: | The presence of a thymocyte population in infant (3 to 10 day old), but not adult mice, that produces IL 2 after self class II MHC antigen stimulation is described. The responding thymocyte expresses the antigenic phenotype: Thy-1+, Ly-1+, Ly-2-, L3T4+, B2A2+. Cell-cell mixing experiments and limiting dilution analysis were consistent with a loss of the self-Ia-reactive IL 2-producing thymocyte in the adult, with no evidence for active suppression found. Although thymocytes from adult animals failed to generate IL 2 after self class II stimulation, a similar frequency of IL 2-producing cells was demonstrated in both infant and adult after allo stimulation. These findings, taken with the recent demonstration of IL 2 receptors on neonatal thymocyte subpopulations, demonstrate a mechanism for IL 2 production in the thymus that may play a role in intrathymic differentiation of T cells. |
| Keywords: | nonhuman; t-lymphocytes; mouse; phenotype; animal; mice; interleukin 2; spleen; mice, inbred balb c; mice, inbred c57bl; lymphocyte culture test, mixed; mice, nude; thymus; infant; stem cells; aging; mice, inbred cba; histocompatibility antigens class ii; cell communication; thymocyte; antigen-presenting cells; interleukin-2; antigens, surface; antigens, differentiation, t-lymphocyte; major histocompatibility antigen; lymphocyte subpopulation; priority journal; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; accessory cell; t-lymphocytes, suppressor-effector |
| Journal Title: | Journal of Immunology |
| Volume: | 136 |
| Issue: | 8 |
| ISSN: | 0022-1767 |
| Publisher: | The American Association of Immunologists, Inc |
| Date Published: | 1986-04-15 |
| Start Page: | 2741 |
| End Page: | 2746 |
| Language: | English |
| PUBMED: | 2937836 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
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